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dc.contributor.advisorTullai, John W.en_US
dc.contributor.advisorBeane-Ebel, Jennifer E.en_US
dc.contributor.authorBehzadi, Fernandaen_US
dc.date.accessioned2019-07-08T14:25:57Z
dc.date.available2019-07-08T14:25:57Z
dc.date.issued2019
dc.identifier.urihttps://hdl.handle.net/2144/36249
dc.description.abstractThe increasing prevalence of drug resistant cancers to conventional therapies remains a major challenge in oncology, emphasizing the need for further research and treatment development. The receptor tyrosine kinase-like orphan receptor 1 (ROR1) presents as a particularly suitable target for cancer therapy, as this type I transmembrane protein is expressed during embryogenesis and up-regulated in various solid and hematological malignancies, but generally repressed in normal adult tissues. A growing cancer literature has established ROR1 as a contributor to cell metastasis and a survival factor for malignant cells, suggesting the therapeutic potential in targeting ROR1 for cancer therapy. The tumor-selective expression of ROR1 has encouraged investigation of novel ROR1-targeted therapies including monoclonal antibodies, small molecule inhibitors, and chimeric antigen receptor T-cells, and preclinical trials have supported their safety and efficacy in inducing tumor growth suppression. Despite these advances in therapeutics, the role of ROR1 in oncogenic signaling is not yet fully understood. Through a comprehensive examination of ROR1 literature, this review will examine the biology of ROR1 as it relates to tumor progression, and demonstrate the viability of current ROR1-targeted therapies.en_US
dc.language.isoen_US
dc.subjectCellular biologyen_US
dc.subjectCanceren_US
dc.subjectCancer therapyen_US
dc.subjectReceptor tyrosine kinaseen_US
dc.titleTherapeutic potential of targeting the oncofetal antigen ROR1en_US
dc.typeThesis/Dissertationen_US
dc.date.updated2019-06-11T01:02:00Z
etd.degree.nameMaster of Scienceen_US
etd.degree.levelmastersen_US
etd.degree.disciplineMedical Sciencesen_US
etd.degree.grantorBoston Universityen_US


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