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dc.contributor.advisorRahimi, Naderen_US
dc.contributor.advisorHenderson, Joelen_US
dc.contributor.authorSutherland, Evan Grahamen_US
dc.date.accessioned2019-07-29T18:11:00Z
dc.date.issued2019
dc.identifier.urihttps://hdl.handle.net/2144/36697
dc.description.abstractRenal cell carcinoma is a high risk and high mortality cancer. While the VHL pathway is frequently altered in renal cell carcinoma, emerging evidences points towards involvement of multiple complex pathways in the progression of renal cell carcinoma. In this present work, we aimed to investigate the role of newly identified protein, Major Intrinsically disordered NOTCH2-Associated Receptor 1 (MINAR1), in renal cell carcinoma. We used immunohistochemistry and demonstrated that MINAR1 is highly expressed in normal kidney epithelium. Furthermore, MINAR1 was expressed at variable levels in human renal cell carcinoma cell lines. More importantly, we found that MINAR1 was significantly downregulated in human samples of renal cell carcinoma. Although further studies are needed, our data suggests a potential role for MINAR1 in renal biology. Given that MINAR1 expression appears to be downregulated in renal cancer patients, it is suggestive that MINAR1 could function as a tumor suppressor.en_US
dc.language.isoen_US
dc.subjectOncologyen_US
dc.subjectccRCCen_US
dc.subjectKIAA1024en_US
dc.subjectKidney canceren_US
dc.subjectMINAR1en_US
dc.subjectRenal canceren_US
dc.titleRole of MINAR1 in renal canceren_US
dc.typeThesis/Dissertationen_US
dc.date.updated2019-06-17T19:19:10Z
dc.description.embargo2020-06-17T00:00:00Z
etd.degree.nameMaster of Scienceen_US
etd.degree.levelmastersen_US
etd.degree.disciplineMedical Sciencesen_US
etd.degree.grantorBoston Universityen_US


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