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dc.contributor.advisorRahimi, Naderen_US
dc.contributor.authorTashjian, Joseph Yeghisheen_US
dc.date.accessioned2019-07-29T19:14:12Z
dc.date.issued2019
dc.identifier.urihttps://hdl.handle.net/2144/36700
dc.description.abstractKidney disease has a high incidence across the globe and can be caused by acute and chronic injury. Current methods of treatment range from prevention and management with diet and extend to hemodialysis at End Stage Renal Disease (ESRD). Transmembrane Immunoglobulin Domain Containing-1 (TMIGD1) is mainly expressed in kidney and the intestines and is involved in cell-cell interaction of epithelial cells. This thesis investigated the potential role of TMIGD1 in the development of chronic kidney disease and tubular epithelial cell injury in CRISPR/Cas9-TMIGD1 transgenic mouse. Treatment of wild-type mice with adenine showed that TMIGD1 is downregulated in response to adenine-induced renal cell injury. CRISPR/Cas9-TMIGD1 -/+ mice treated with adenine displayed significantly increased tubular damage compared to wild-type mice. Additionally, expression of TMIGD1 was directly correlated with localization of C/EBPβ to nucleus, a transcription factor that is known to regulate expression of TMIGD1. In conclusion, the loss of TMIGD1 negatively impacts response to renal stress.en_US
dc.language.isoen_US
dc.subjectPathologyen_US
dc.subjectAdenineen_US
dc.subjectEpithelialen_US
dc.subjectRenalen_US
dc.subjectTMIGD1en_US
dc.subjectTubuleen_US
dc.titleThe role of transmembrane immunoglobulin domain containing-1 (TMIGD1) in renal epithelial cellsen_US
dc.typeThesis/Dissertationen_US
dc.date.updated2019-06-17T19:19:25Z
dc.description.embargo2020-06-17T00:00:00Z
etd.degree.nameMaster of Scienceen_US
etd.degree.levelmastersen_US
etd.degree.disciplinePathologyen_US
etd.degree.grantorBoston Universityen_US


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