Characterization of IGCR-1: a novel molecule with potential roles in lung carcinogenesis
Lam, Christa Mercy
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Non-small cell lung cancer (NSCLC) patients respond poorly to generic chemotherapeutics. Despite recent advancements in the treatment of NSCLC, the overall five-year survival rate of NSCLC remains low at 14.6%. We have identified Immunoglobulin-containing and Cysteine-rich Receptor (IGCR-1) as a putative cell surface protein, which is expressed in lung epithelial cells. The main objectives of this study were to evaluate expression of IGCR-1 in normal lung epithelium and lung carcinoma. Our analysis of publicly available ATCG data via bioGPS revealed that IGCR-1 is highly expressed in human lung. Moreover, our immunohistochemical studies further confirmed that IGCR-1 is expressed in bronchial epithelial cells. Additionally, IGCR-1 is expressed in endothelial cells of blood vessels and localized on the cell surface of human embryonic kidney cells. Its cell surface localization suggests that IGCR-1 could be a cellular adhesion molecule (CAM) with roles in the tumor microenvironment. Of note, the analysis of a panel of human lung carcinoma cell lines via western blot analysis demonstrated that IGCR-1 is expressed at variable levels in these cell lines. Given the heterogeneity of NSCLSs and the corresponding differential expression of IGCR-1 in different lung cancer cell lines, IGCR-1 may play an important role in NSCLCs.
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