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dc.contributor.advisorRahimi, Naderen_US
dc.contributor.authorLam, Christa Mercyen_US
dc.date.accessioned2019-07-30T14:34:45Z
dc.date.issued2019
dc.identifier.urihttps://hdl.handle.net/2144/36708
dc.description.abstractNon-small cell lung cancer (NSCLC) patients respond poorly to generic chemotherapeutics. Despite recent advancements in the treatment of NSCLC, the overall five-year survival rate of NSCLC remains low at 14.6%. We have identified Immunoglobulin-containing and Cysteine-rich Receptor (IGCR-1) as a putative cell surface protein, which is expressed in lung epithelial cells. The main objectives of this study were to evaluate expression of IGCR-1 in normal lung epithelium and lung carcinoma. Our analysis of publicly available ATCG data via bioGPS revealed that IGCR-1 is highly expressed in human lung. Moreover, our immunohistochemical studies further confirmed that IGCR-1 is expressed in bronchial epithelial cells. Additionally, IGCR-1 is expressed in endothelial cells of blood vessels and localized on the cell surface of human embryonic kidney cells. Its cell surface localization suggests that IGCR-1 could be a cellular adhesion molecule (CAM) with roles in the tumor microenvironment. Of note, the analysis of a panel of human lung carcinoma cell lines via western blot analysis demonstrated that IGCR-1 is expressed at variable levels in these cell lines. Given the heterogeneity of NSCLSs and the corresponding differential expression of IGCR-1 in different lung cancer cell lines, IGCR-1 may play an important role in NSCLCs.en_US
dc.language.isoen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectBiochemistryen_US
dc.titleCharacterization of IGCR-1: a novel molecule with potential roles in lung carcinogenesisen_US
dc.typeThesis/Dissertationen_US
dc.date.updated2019-06-17T19:19:43Z
dc.description.embargo2020-06-17T00:00:00Z
etd.degree.nameMaster of Scienceen_US
etd.degree.levelmastersen_US
etd.degree.disciplineMedical Sciencesen_US
etd.degree.grantorBoston Universityen_US


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International