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dc.contributor.authorJohn, Yohan J.en_US
dc.contributor.authorZikopoulos, Basilisen_US
dc.contributor.authorBullock, Danielen_US
dc.contributor.authorBarbas, Helenen_US
dc.coverage.spatialUnited Statesen_US
dc.date2018-10-17
dc.date.accessioned2019-08-06T17:09:18Z
dc.date.available2019-08-06T17:09:18Z
dc.date.issued2018-12
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/30627672
dc.identifier.citationYohan J. John, Basilis Zikopoulos, Daniel Bullock, Helen Barbas. 2018. "Visual attention deficits in schizophrenia can arise from inhibitory dysfunction in thalamus or cortex." Comput Psychiatr, Volume 2, pp. 223 - 257. https://doi.org/10.1162/cpsy_a_00023
dc.identifier.issn2379-6227
dc.identifier.urihttps://hdl.handle.net/2144/37018
dc.description.abstractSchizophrenia is associated with diverse cognitive deficits, including disorders of attention-related oculomotor behavior. At the structural level, schizophrenia is associated with abnormal inhibitory control in the circuit linking cortex and thalamus. We developed a spiking neural network model that demonstrates how dysfunctional inhibition can degrade attentive gaze control. Our model revealed that perturbations of two functionally distinct classes of cortical inhibitory neurons, or of the inhibitory thalamic reticular nucleus, disrupted processing vital for sustained attention to a stimulus, leading to distractibility. Because perturbation at each circuit node led to comparable but qualitatively distinct disruptions in attentive tracking or fixation, our findings support the search for new eye movement metrics that may index distinct underlying neural defects. Moreover, because the cortico-thalamic circuit is a common motif across sensory, association, and motor systems, the model and extensions can be broadly applied to study normal function and the neural bases of other cognitive deficits in schizophrenia.en_US
dc.description.sponsorshipR01 MH057414 - NIMH NIH HHS; R01 MH101209 - NIMH NIH HHS; R01 NS024760 - NINDS NIH HHSen_US
dc.format.extent223 - 257en_US
dc.languageeng
dc.publisherMIT Press - Journalsen_US
dc.relation.ispartofComputational Psychiatry
dc.subjectGABAen_US
dc.subjectNMDAen_US
dc.subjectcalbindin neuronsen_US
dc.subjectcomputational modelen_US
dc.subjectdisinhibitionen_US
dc.subjectparvalbumin neuronsen_US
dc.subjectpsychiatryen_US
dc.subjectspikingen_US
dc.subjectthalamic reticular nucleusen_US
dc.titleVisual attention deficits in schizophrenia can arise from inhibitory dysfunction in thalamus or cortexen_US
dc.typeArticleen_US
dc.description.versionPublished versionen_US
dc.identifier.doi10.1162/cpsy_a_00023
pubs.elements-sourcepubmeden_US
pubs.notesEmbargo: Not knownen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Arts & Sciencesen_US
pubs.organisational-groupBoston University, College of Arts & Sciences, Department of Psychological & Brain Sciencesen_US
pubs.organisational-groupBoston University, College of Health & Rehabilitation Sciences: Sargent Collegeen_US
pubs.organisational-groupBoston University, College of Health & Rehabilitation Sciences: Sargent College, Health Sciencesen_US
pubs.publication-statusPublisheden_US
dc.identifier.orcid0000-0003-0825-0832 (Barbas, Helen)
dc.identifier.mycv416540


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