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dc.contributor.authorMagnani, Christopheen_US
dc.contributor.authorEconomo, Michael N.en_US
dc.contributor.authorWhite, John A.en_US
dc.contributor.authorMoore, Lee E.en_US
dc.date.accessioned2019-09-03T19:32:14Z
dc.date.available2019-09-03T19:32:14Z
dc.date.issued2014-08-19
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000341943500001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=6e74115fe3da270499c3d65c9b17d654
dc.identifier.citationChristophe Magnani, Michael N Economo, John A White, Lee E Moore. 2014. "Nonlinear properties of medial entorhinal cortex neurons reveal frequency selectivity during multi-sinusoidal stimulation." FRONTIERS IN CELLULAR NEUROSCIENCE, Volume 8. https://doi.org/10.3389/fncel.2014.00239
dc.identifier.issn1662-5102
dc.identifier.urihttps://hdl.handle.net/2144/37642
dc.description.abstractThe neurons in layer II of the medial entorhinal cortex are part of the grid cell network involved in the representation of space. Many of these neurons are likely to be stellate cells with specific oscillatory and firing properties important for their function. A fundamental understanding of the nonlinear basis of these oscillatory properties is critical for the development of theories of grid cell firing. In order to evaluate the behavior of stellate neurons, measurements of their quadratic responses were used to estimate a second order Volterra kernel. This paper uses an operator theory, termed quadratic sinusoidal analysis (QSA), which quantitatively determines that the quadratic response accounts for a major part of the nonlinearity observed at membrane potential levels characteristic of normal synaptic events. Practically, neurons were probed with multi-sinusoidal stimulations to determine a Hermitian operator that captures the quadratic function in the frequency domain. We have shown that the frequency content of the stimulation plays an important role in the characteristics of the nonlinear response, which can distort the linear response as well. Stimulations with enhanced low frequency amplitudes evoked a different nonlinear response than broadband profiles. The nonlinear analysis was also applied to spike frequencies and it was shown that the nonlinear response of subthreshold membrane potential at resonance frequencies near the threshold is similar to the nonlinear response of spike trains.en_US
dc.description.sponsorshipResearch reported in this paper was supported by the National Institutes of Health under award numbers NIH R01 EB016407 and NIH R01 MH085074. We wish to thank Dr. Lyle Graham for helpful comments. (NIH R01 EB016407 - National Institutes of Health; NIH R01 MH085074 - National Institutes of Health)en_US
dc.format.extent(16)en_US
dc.languageEnglish
dc.publisherFRONTIERS MEDIA SAen_US
dc.relation.ispartofFRONTIERS IN CELLULAR NEUROSCIENCE
dc.rightsCopyright © 2014 Magnani, Economo, White and Moore. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectLife sciences & biomedicineen_US
dc.subjectNeurosciencesen_US
dc.subjectNeurosciences & neurologyen_US
dc.subjectEntorhinal cortexen_US
dc.subjectStellate neuronsen_US
dc.subjectGrid cellsen_US
dc.subjectQuadratic sinusoidal analysisen_US
dc.subjectFrequency domainen_US
dc.subjectNonlinear oscillationsen_US
dc.subjectResonanceen_US
dc.titleNonlinear properties of medial entorhinal cortex neurons reveal frequency selectivity during multi-sinusoidal stimulationen_US
dc.typeArticleen_US
dc.description.versionPublished versionen_US
dc.identifier.doi10.3389/fncel.2014.00239
pubs.elements-sourceweb-of-scienceen_US
pubs.notesEmbargo: No embargoen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Engineeringen_US
pubs.organisational-groupBoston University, College of Engineering, Department of Biomedical Engineeringen_US
pubs.publication-statusPublisheden_US
dc.identifier.orcid0000-0003-1073-2638 (White, John A)
dc.identifier.mycv176033


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Copyright © 2014 Magnani, Economo, White and Moore. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Except where otherwise noted, this item's license is described as Copyright © 2014 Magnani, Economo, White and Moore. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.