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dc.contributor.authorEconomo, Michael N.en_US
dc.contributor.authorWinnubst, Johanen_US
dc.contributor.authorBas, Erhanen_US
dc.contributor.authorFerreira, Tiago A.en_US
dc.contributor.authorChandrashekar, Jayaramen_US
dc.coverage.spatialUnited Statesen_US
dc.date2019-02-19
dc.date.accessioned2019-09-03T19:34:39Z
dc.date.available2019-09-03T19:34:39Z
dc.date.issued2019-09-01
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/30859571
dc.identifier.citationMichael N Economo, Johan Winnubst, Erhan Bas, Tiago A Ferreira, Jayaram Chandrashekar. 2019. "Single-neuron axonal reconstruction: The search for a wiring diagram of the brain.." J Comp Neurol, Volume 527, Issue 13, pp. 2190 - 2199. https://doi.org/10.1002/cne.24674
dc.identifier.issn1096-9861
dc.identifier.urihttps://hdl.handle.net/2144/37643
dc.description.abstractReconstruction of the axonal projection patterns of single neurons has been an important tool for understanding both the diversity of cell types in the brain and the logic of information flow between brain regions. Innovative approaches now enable the complete reconstruction of axonal projection patterns of individual neurons with vastly increased throughput. Here, we review how advances in genetic, imaging, and computational techniques have been exploited for axonal reconstruction. We also discuss how new innovations could enable the integration of genetic and physiological information with axonal morphology for producing a census of cell types in the mammalian brain at scale.en_US
dc.description.abstractReconstruction of the axonal projection patterns of single neurons has been an important tool for understanding both the diversity of cell types in the brain and the logic of information flow between brain regions. Innovative approaches now enable the complete reconstruction of axonal projection patterns of individual neurons with vastly increased throughput. Here, we review how advances in genetic, imaging, and computational techniques have been exploited for axonal reconstruction. We also discuss how new innovations could enable the integration of genetic and physiological information with axonal morphology for producing a census of cell types in the mammalian brain at scale.en_US
dc.format.extent2190 - 2199en_US
dc.languageeng
dc.relation.ispartofJ Comp Neurol
dc.subjectAxonal reconstructionen_US
dc.subjectLong-range circuitsen_US
dc.subjectWhole-brain imagingen_US
dc.subjectNeurosciencesen_US
dc.subjectZoologyen_US
dc.subjectMedical physiologyen_US
dc.subjectNeurology & neurosurgeryen_US
dc.titleSingle-neuron axonal reconstruction: The search for a wiring diagram of the brainen_US
dc.typeArticleen_US
dc.description.versionFirst author draften_US
dc.identifier.doi10.1002/cne.24674
pubs.elements-sourcepubmeden_US
pubs.notesEmbargo: No embargoen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Engineeringen_US
pubs.organisational-groupBoston University, College of Engineering, Department of Biomedical Engineeringen_US
pubs.publication-statusPublisheden_US
dc.identifier.mycv452792


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