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    Shear-induced diffusion of red blood cells measured with dynamic light scattering-optical coherence tomography

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    Date Issued
    2018-02
    Publisher Version
    10.1002/jbio.201700070
    Author(s)
    Tang, Jianbo
    Erdener, Sefik Evren
    Li, Baoqiang
    Fu, Buyin
    Sakadzic, Sava
    Carp, Stefan A.
    Lee, Jonghwan
    Boas, David A.
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    Permanent Link
    https://hdl.handle.net/2144/37645
    OA Version
    Accepted manuscript
    Citation (published version)
    Jianbo Tang, Sefik Evren Erdener, Baoqiang Li, Buyin Fu, Sava Sakadzic, Stefan A Carp, Jonghwan Lee, David A Boas. 2018. "Shear-induced diffusion of red blood cells measured with dynamic light scattering-optical coherence tomography.." J Biophotonics, Volume 11, Issue 2, https://doi.org/10.1002/jbio.201700070
    Abstract
    Quantitative measurements of intravascular microscopic dynamics, such as absolute blood flow velocity, shear stress and the diffusion coefficient of red blood cells (RBCs), are fundamental in understanding the blood flow behavior within the microcirculation, and for understanding why diffuse correlation spectroscopy (DCS) measurements of blood flow are dominantly sensitive to the diffusive motion of RBCs. Dynamic light scattering-optical coherence tomography (DLS-OCT) takes the advantages of using DLS to measure particle flow and diffusion within an OCT resolution-constrained three-dimensional volume, enabling the simultaneous measurements of absolute RBC velocity and diffusion coefficient with high spatial resolution. In this work, we applied DLS-OCT to measure both RBC velocity and the shear-induced diffusion coefficient within penetrating venules of the somatosensory cortex of anesthetized mice. Blood flow laminar profile measurements indicate a blunted laminar flow profile and the degree of blunting decreases with increasing vessel diameter. The measured shear-induced diffusion coefficient was proportional to the flow shear rate with a magnitude of ~0.1 to 0.5 × 10-6  mm2 . These results provide important experimental support for the recent theoretical explanation for why DCS is dominantly sensitive to RBC diffusive motion.
    Description
    Published in final edited form as: J Biophotonics. 2018 February ; 11(2): . doi:10.1002/jbio.201700070.
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    • ENG: Biomedical Engineering: Scholarly Papers [270]
    • BU Open Access Articles [3730]


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