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    Characterizing the optical properties of human brain tissue with high numerical aperture optical coherence tomography

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    Date Issued
    2017-12-01
    Publisher Version
    10.1364/BOE.8.005617
    Author(s)
    Wang, Hui
    Magnain, Caroline
    Sakadžić, Sava
    Fischl, Bruce
    Boas, David A.
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    Permanent Link
    https://hdl.handle.net/2144/37649
    OA Version
    Published version
    Citation (published version)
    Hui Wang, Caroline Magnain, Sava Sakadžić, Bruce Fischl, David A Boas. 2017. "Characterizing the optical properties of human brain tissue with high numerical aperture optical coherence tomography.." Biomed Opt Express, Volume 8, Issue 12, pp. 5617 - 5636. https://doi.org/10.1364/BOE.8.005617
    Abstract
    Quantification of tissue optical properties with optical coherence tomography (OCT) has proven to be useful in evaluating structural characteristics and pathological changes. Previous studies primarily used an exponential model to analyze low numerical aperture (NA) OCT measurements and obtain the total attenuation coefficient for biological tissue. In this study, we develop a systematic method that includes the confocal parameter for modeling the depth profiles of high NA OCT, when the confocal parameter cannot be ignored. This approach enables us to quantify tissue optical properties with higher lateral resolution. The model parameter predictions for the scattering coefficients were tested with calibrated microsphere phantoms. The application of the model to human brain tissue demonstrates that the scattering and back-scattering coefficients each provide unique information, allowing us to differentially identify laminar structures in primary visual cortex and distinguish various nuclei in the midbrain. The combination of the two optical properties greatly enhances the power of OCT to distinguish intricate structures in the human brain beyond what is achievable with measured OCT intensity information alone, and therefore has the potential to enable objective evaluation of normal brain structure as well as pathological conditions in brain diseases. These results represent a promising step for enabling the quantification of tissue optical properties from high NA OCT.
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    © 2017 Optical Society of America. Users may use, reuse, and build upon the article, or use the article for text or data mining, so long as such uses are for non-commercial purposes and appropriate attribution is maintained. All other rights are reserved.
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    • ENG: Biomedical Engineering: Scholarly Papers [273]
    • BU Open Access Articles [3855]


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