Show simple item record

dc.contributor.authorWang, Huien_US
dc.contributor.authorMagnain, Carolineen_US
dc.contributor.authorSakadžić, Savaen_US
dc.contributor.authorFischl, Bruceen_US
dc.contributor.authorBoas, David A.en_US
dc.coverage.spatialUnited Statesen_US
dc.date2017-11-08
dc.date.accessioned2019-09-04T13:22:59Z
dc.date.available2019-09-04T13:22:59Z
dc.date.issued2017-12-01
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/29296492
dc.identifier.citationHui Wang, Caroline Magnain, Sava Sakadžić, Bruce Fischl, David A Boas. 2017. "Characterizing the optical properties of human brain tissue with high numerical aperture optical coherence tomography.." Biomed Opt Express, Volume 8, Issue 12, pp. 5617 - 5636. https://doi.org/10.1364/BOE.8.005617
dc.identifier.issn2156-7085
dc.identifier.urihttps://hdl.handle.net/2144/37649
dc.description.abstractQuantification of tissue optical properties with optical coherence tomography (OCT) has proven to be useful in evaluating structural characteristics and pathological changes. Previous studies primarily used an exponential model to analyze low numerical aperture (NA) OCT measurements and obtain the total attenuation coefficient for biological tissue. In this study, we develop a systematic method that includes the confocal parameter for modeling the depth profiles of high NA OCT, when the confocal parameter cannot be ignored. This approach enables us to quantify tissue optical properties with higher lateral resolution. The model parameter predictions for the scattering coefficients were tested with calibrated microsphere phantoms. The application of the model to human brain tissue demonstrates that the scattering and back-scattering coefficients each provide unique information, allowing us to differentially identify laminar structures in primary visual cortex and distinguish various nuclei in the midbrain. The combination of the two optical properties greatly enhances the power of OCT to distinguish intricate structures in the human brain beyond what is achievable with measured OCT intensity information alone, and therefore has the potential to enable objective evaluation of normal brain structure as well as pathological conditions in brain diseases. These results represent a promising step for enabling the quantification of tissue optical properties from high NA OCT.en_US
dc.description.sponsorshipP01 NS055104 - NINDS NIH HHS; R01 NS091230 - NINDS NIH HHS; S10 RR029050 - NCRR NIH HHSen_US
dc.description.urihttps://www.ncbi.nlm.nih.gov/pubmed/29296492
dc.format.extent5617 - 5636en_US
dc.languageeng
dc.relation.ispartofBiomed Opt Express
dc.rights© 2017 Optical Society of America. Users may use, reuse, and build upon the article, or use the article for text or data mining, so long as such uses are for non-commercial purposes and appropriate attribution is maintained. All other rights are reserved.en_US
dc.subjectLight propagation in tissuesen_US
dc.subjectMedical and biological imagingen_US
dc.subjectOptical coherence tomographyen_US
dc.subjectTissue characterizationen_US
dc.subjectScatteringen_US
dc.titleCharacterizing the optical properties of human brain tissue with high numerical aperture optical coherence tomographyen_US
dc.typeArticleen_US
dc.identifier.doi10.1364/BOE.8.005617
pubs.elements-sourcepubmeden_US
pubs.notesEmbargo: Not knownen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Engineeringen_US
pubs.organisational-groupBoston University, College of Engineering, Department of Biomedical Engineeringen_US
pubs.publication-statusPublished onlineen_US
dc.identifier.orcid0000-0002-6709-7711 (Boas, David A)
dc.description.oaversionPublished version
dc.identifier.mycv307513


This item appears in the following Collection(s)

Show simple item record