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dc.contributor.authorLeproux, Anaisen_US
dc.contributor.authorO'Sullivan, Thomas D.en_US
dc.contributor.authorCerussi, Alberten_US
dc.contributor.authorDurkin, Amandaen_US
dc.contributor.authorHill, Brianen_US
dc.contributor.authorHylton, Nolaen_US
dc.contributor.authorYodh, Arjun G.en_US
dc.contributor.authorCarp, Stefan A.en_US
dc.contributor.authorBoas, Daviden_US
dc.contributor.authorJiang, Shudongen_US
dc.contributor.authorPaulsen, Keith D.en_US
dc.contributor.authorPogue, Brianen_US
dc.contributor.authorRoblyer, Darrenen_US
dc.contributor.authorYang, Weien_US
dc.contributor.authorTromberg, Bruce J.en_US
dc.date.accessioned2019-09-04T14:45:26Z
dc.date.available2019-09-04T14:45:26Z
dc.date.issued2017-12-01
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000419961000004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=6e74115fe3da270499c3d65c9b17d654
dc.identifier.citationAnaïs Leproux, Thomas D. O’Sullivan, Albert Cerussi, Amanda Durkin, Brian Hill, Nola Hylton, Arjun G. Yodh, Stefan A. Carp, David Boas, Shudong Jiang, Keith D. Paulsen, Brian Pogue, Darren Roblyer, Wei Yang, Bruce J. Tromberg, “Performance assessment of diffuse optical spectroscopic imaging instruments in a 2-year multicenter breast cancer trial,” J. Biomed. Opt. 22(12), 121604 (2017), https://doi.org/10.1117/1.JBO.22.12.121604
dc.identifier.issn1083-3668
dc.identifier.issn1560-2281
dc.identifier.urihttps://hdl.handle.net/2144/37652
dc.description.abstractWe present a framework for characterizing the performance of an experimental imaging technology, diffuse optical spectroscopic imaging (DOSI), in a 2-year multicenter American College of Radiology Imaging Network (ACRIN) breast cancer study (ACRIN-6691). DOSI instruments combine broadband frequency-domain photon migration with time-independent near-infrared (650 to 1000 nm) spectroscopy to measure tissue absorption and reduced scattering spectra and tissue hemoglobin, water, and lipid composition. The goal of ACRIN-6691 was to test the effectiveness of optically derived imaging endpoints in predicting the final pathologic response of neoadjuvant chemotherapy (NAC). Sixty patients were enrolled over a 2-year period at participating sites and received multiple DOSI scans prior to and during 3- to 6-month NAC. The impact of three sources of error on accuracy and precision, including different operators, instruments, and calibration standards, was evaluated using a broadband reflectance standard and two different solid tissue-simulating optical phantoms. Instruments showed <0.0010  mm−1 (10.3%) and 0.06  mm−1 (4.7%) deviation in broadband absorption and reduced scattering, respectively, over the 2-year duration of ACRIN-6691. These variations establish a useful performance criterion for assessing instrument stability. The proposed procedures and tests are not limited to DOSI; rather, they are intended to provide methods to characterize performance of any instrument used in translational optical imaging.en_US
dc.description.sponsorshipThe authors thank the DOSI operators at all sites: Ylenia Santoro, Montana Compton, Kelly Michaelsen, Tracy Frazee, Madeline Winters, So Hyun Chung, Erin Buckley, Krysta Banfield, Roxana Dhada, Amir Sajjadi, Kaley Mitchell, Sarah Grundy, and Jennifer Lynch. This research was supported by ACRIN, which receives funding from the NCI through U01 CA079778 and U01 CA080098, the National Institute of Biomedical Imaging and Bioengineering (No. P41EB015890), the Center for Magnetic Resonance and Optical Imaging (No. P41 EB015893), the National Cancer Institute (Nos. R01CA142989 and U54CA136400), the Chao Family Comprehensive Cancer Center (No. P30CA62203), and programmatic support from the Arnold and Mabel Beckman Foundation. The DOSI instrumentation used in this study was constructed in a university laboratory using federal grant support (NIH). (U01 CA079778 - ACRIN - NCI; U01 CA080098 - ACRIN - NCI; P41EB015890 - National Institute of Biomedical Imaging and Bioengineering; P41 EB015893 - Center for Magnetic Resonance and Optical Imaging; R01CA142989 - National Cancer Institute; U54CA136400 - National Cancer Institute; P30CA62203 - Chao Family Comprehensive Cancer Center; Arnold and Mabel Beckman Foundation; NIH)en_US
dc.description.urihttp://apps.webofknowledge.com/InboundService.do?customersID=LinksAMR&mode=FullRecord&IsProductCode=Yes&product=WOS&Init=Yes&Func=Frame&DestFail=http:%2F%2Fwww.webofknowledge.com&action=retrieve&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&SID=7F7agXse9pkHhfQhT7z&UT=WOS:000419961000004
dc.description.urihttp://apps.webofknowledge.com/InboundService.do?customersID=LinksAMR&mode=FullRecord&IsProductCode=Yes&product=WOS&Init=Yes&Func=Frame&DestFail=http:%2F%2Fwww.webofknowledge.com&action=retrieve&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&SID=7F7agXse9pkHhfQhT7z&UT=WOS:000419961000004
dc.format.extent(10)en_US
dc.languageEnglish
dc.publisherSPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERSen_US
dc.relation.ispartofJOURNAL OF BIOMEDICAL OPTICS
dc.rights© The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI. [DOI: 10.1117/1.JBO.22.12.121604]en_US
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/
dc.subjectLife sciences & biomedicineen_US
dc.subjectPhysical sciencesen_US
dc.subjectBiochemical research methodsen_US
dc.subjectOpticsen_US
dc.subjectRadiology, nuclear medicine & medical imagingen_US
dc.subjectBiochemistry & molecular biologyen_US
dc.subjectDiffuse opticsen_US
dc.subjectFrequency-domain photon migrationen_US
dc.subjectIndependent near-infrared spectroscopyen_US
dc.subjectNeoadjuvant chemotherapyen_US
dc.subjectFunctional imagingen_US
dc.subjectBreast neoplasmsen_US
dc.subjectChemotherapy, adjuvanten_US
dc.subjectClinical trials as topicen_US
dc.subjectDrug monitoringen_US
dc.subjectEquipment designen_US
dc.subjectFemaleen_US
dc.subjectHumansen_US
dc.subjectOptical imagingen_US
dc.subjectPhantoms, imagingen_US
dc.subjectSpectroscopy, near-Infrareden_US
dc.subjectHumansen_US
dc.subjectOptical physicsen_US
dc.subjectOpthalmology and optometryen_US
dc.subjectBiomedical engineeringen_US
dc.subjectOpticsen_US
dc.titlePerformance assessment of diffuse optical spectroscopic imaging instruments in a 2-year multicenter breast canceren_US
dc.typeArticleen_US
dc.identifier.doi10.1117/1.JBO.22.12.121604
pubs.elements-sourceweb-of-scienceen_US
pubs.notesEmbargo: Not knownen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Engineeringen_US
pubs.organisational-groupBoston University, College of Engineering, Department of Biomedical Engineeringen_US
pubs.publication-statusPublisheden_US
dc.identifier.orcid0000-0002-6709-7711 (Boas, David)
dc.description.oaversionPublished version
dc.identifier.mycv324187


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© The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI. [DOI: 10.1117/1.JBO.22.12.121604]
Except where otherwise noted, this item's license is described as © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI. [DOI: 10.1117/1.JBO.22.12.121604]