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dc.contributor.authorPeng, Keen_US
dc.contributor.authorYucel, Meryem A.en_US
dc.contributor.authorAasted, Christopher M.en_US
dc.contributor.authorSteele, Sarah C.en_US
dc.contributor.authorBoas, David A.en_US
dc.contributor.authorBorsook, Daviden_US
dc.contributor.authorBecerra, Linoen_US
dc.date.accessioned2019-09-04T18:26:59Z
dc.date.available2019-09-04T18:26:59Z
dc.date.issued2018-01-01
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000429587200018&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=6e74115fe3da270499c3d65c9b17d654
dc.identifier.citationKe Peng, Meryem A. Yücel, Christopher M. Aasted, Sarah C. Steele, David A. Boas, David Borsook, and Lino Becerra "Using prerecorded hemodynamic response functions in detecting prefrontal pain response: a functional near-infrared spectroscopy study," Neurophotonics 5(1), 011018 (16 October 2017). https://doi.org/10.1117/1.NPh.5.1.011018
dc.identifier.issn2329-423X
dc.identifier.issn2329-4248
dc.identifier.urihttps://hdl.handle.net/2144/37662
dc.description.abstractCurrently, there is no method for providing a nonverbal objective assessment of pain. Recent work using functional near-infrared spectroscopy (fNIRS) has revealed its potential for objective measures. We conducted two fNIRS scans separated by 30 min and measured the hemodynamic response to the electrical noxious and innocuous stimuli over the anterior prefrontal cortex (aPFC) in 14 subjects. Based on the estimated hemodynamic response functions (HRFs), we first evaluated the test–retest reliability of using fNIRS in measuring the pain response over the aPFC. We then proposed a general linear model (GLM)-based detection model that employs the subject-specific HRFs from the first scan to detect the pain response in the second scan. Our results indicate that fNIRS has a reasonable reliability in detecting the hemodynamic changes associated with noxious events, especially in the medial portion of the aPFC. Compared with a standard HRF with a fixed shape, including the subject-specific HRFs in the GLM allows for a significant improvement in the detection sensitivity of aPFC pain response. This study supports the potential application of individualized analysis in using fNIRS and provides a robust model to perform objective determination of pain perception.en_US
dc.description.sponsorshipThis study was supported by the National Institutes of Health (NIH) and the National Institute of General Medical Sciences (NIGMS) Grant No. NIH-NIGMS 1-R01-GM104986. (National Institutes of Health (NIH); NIH-NIGMS 1-R01-GM104986 - National Institute of General Medical Sciences (NIGMS))en_US
dc.description.urihttps://www.spiedigitallibrary.org/journals/neurophotonics/volume-5/issue-01/011018/Using-prerecorded-hemodynamic-response-functions-in-detecting-prefrontal-pain-response/10.1117/1.NPh.5.1.011018.full
dc.description.urihttps://www.spiedigitallibrary.org/journals/neurophotonics/volume-5/issue-01/011018/Using-prerecorded-hemodynamic-response-functions-in-detecting-prefrontal-pain-response/10.1117/1.NPh.5.1.011018.full
dc.format.extent(15)en_US
dc.languageEnglish
dc.publisherSPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERSen_US
dc.relation.ispartofNEUROPHOTONICS
dc.rights© 2017 Society of Photo-Optical Instrumentation Engineers (SPIE)en_US
dc.subjectLife sciences & biomedicineen_US
dc.subjectNeurosciencesen_US
dc.subjectOpticsen_US
dc.subjectNeurosciences & neurologyen_US
dc.subjectHemodynamic response functionen_US
dc.subjectPainen_US
dc.subjectTest-retest reliabilityen_US
dc.subjectAnterior prefrontal cortexen_US
dc.subjectDetection sensitivityen_US
dc.subjectNear-infrared spectroscopyen_US
dc.subjectFMRIen_US
dc.subjectFNIRSen_US
dc.titleUsing prerecorded hemodynamic response functions in detecting prefrontal pain response: a functional near-infrared spectroscopy studyen_US
dc.typeArticleen_US
dc.identifier.doi10.1117/1.NPh.5.1.011018
pubs.elements-sourceweb-of-scienceen_US
pubs.notesEmbargo: Not knownen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Engineeringen_US
pubs.organisational-groupBoston University, College of Engineering, Department of Biomedical Engineeringen_US
pubs.publication-statusPublisheden_US
dc.identifier.orcid0000-0002-4291-2847 (Yucel, Meryem A)
dc.identifier.orcid0000-0002-6709-7711 (Boas, David A)
dc.description.oaversionPublished version
dc.identifier.mycv287379


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