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dc.contributor.authorPerkins, L. Nathanen_US
dc.contributor.authorDevor, Annaen_US
dc.contributor.authorGardner, Timothy J.en_US
dc.contributor.authorBoas, David A.en_US
dc.date.accessioned2019-09-05T16:12:36Z
dc.date.available2019-09-05T16:12:36Z
dc.date.issued2018-10-01
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000456860100012&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=6e74115fe3da270499c3d65c9b17d654
dc.identifier.citationL Nathan Perkins, Anna Devor, Timothy J Gardner, David A Boas. 2018. "Extracting individual neural activity recorded through splayed optical microfibers." NEUROPHOTONICS, Volume 5, Issue 4. https://doi.org/10.1117/1.NPh.5.4.045009
dc.identifier.issn2329-423X
dc.identifier.issn2329-4248
dc.identifier.urihttps://hdl.handle.net/2144/37733
dc.description.abstractPreviously introduced bundles of hundreds or thousands of microfibers have the potential to extend optical access to deep brain regions, sampling fluorescence activity throughout a three-dimensional volume. Each fiber has a small diameter (8  μm) and follows a path of least resistance, splaying during insertion. By superimposing the fiber sensitivity profile for each fiber, we model the interface properties for a simulated neural population. Our modeling results suggest that for small (<200) bundles of fibers, each fiber will collect fluorescence from a small number of nonoverlapping neurons near the fiber apertures. As the number of fibers increases, the bundle delivers more uniform excitation power to the region, moving to a regime where fibers collect fluorescence from more neurons and there is greater overlap between neighboring fibers. Under these conditions, it becomes feasible to apply source separation to extract individual neural contributions. In addition, we demonstrate a source separation technique particularly suited to the interface. Our modeling helps establish performance expectations for this interface and provides a framework for estimating neural contributions under a range of conditions.en_US
dc.description.sponsorshipThis work was supported by the National Eye Institute (No. R21, EY027588-01). (EY027588-01 - National Eye Institute)en_US
dc.description.urihttps://www.spiedigitallibrary.org/journals/neurophotonics/volume-5/issue-04/045009/Extracting-individual-neural-activity-recorded-through-splayed-optical-microfibers/10.1117/1.NPh.5.4.045009.full
dc.format.extent(10)en_US
dc.languageEnglish
dc.publisherSPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERSen_US
dc.relation.ispartofNEUROPHOTONICS
dc.rights© The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI: https://doi.org/10.1117/1.NPh.5.4.045009en_US
dc.subjectLife sciences & biomedicineen_US
dc.subjectPhysical sciencesen_US
dc.subjectNeurosciencesen_US
dc.subjectOpticsen_US
dc.subjectNeurosciences & neurologyen_US
dc.subjectImaging systemsen_US
dc.subjectIn vivo imagingen_US
dc.subjectFluorescenceen_US
dc.subjectNeurophotonicsen_US
dc.titleExtracting individual neural activity recorded through splayed optical microfibersen_US
dc.typeArticleen_US
dc.identifier.doi10.1117/1.NPh.5.4.045009
pubs.elements-sourceweb-of-scienceen_US
pubs.notesEmbargo: Not knownen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Arts & Sciencesen_US
pubs.organisational-groupBoston University, College of Arts & Sciences, Department of Biologyen_US
pubs.organisational-groupBoston University, College of Engineeringen_US
pubs.organisational-groupBoston University, College of Engineering, Department of Biomedical Engineeringen_US
pubs.publication-statusPublisheden_US
dc.identifier.orcid0000-0002-6709-7711 (Boas, David A)
dc.description.oaversionPublished version
dc.identifier.mycv416827


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