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dc.contributor.authorSelb, Julietteen_US
dc.contributor.authorWu, Kuan-Chengen_US
dc.contributor.authorSutin, Jasonen_US
dc.contributor.authorLin, Pei-Yi Ivyen_US
dc.contributor.authorFarzam, Parisaen_US
dc.contributor.authorBechek, Sophiaen_US
dc.contributor.authorShenoy, Apekshaen_US
dc.contributor.authorPatel, Aman B.en_US
dc.contributor.authorBoas, David A.en_US
dc.contributor.authorFranceschini, Maria Angelaen_US
dc.contributor.authorRosenthal, Eric S.en_US
dc.coverage.spatialUnited Statesen_US
dc.date2018-09-24
dc.date.accessioned2019-09-05T16:59:17Z
dc.date.available2019-09-05T16:59:17Z
dc.date.issued2018-10
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/30450363
dc.identifier.citationJuliette Selb, Kuan-Cheng Wu, Jason Sutin, Pei-Yi Ivy Lin, Parisa Farzam, Sophia Bechek, Apeksha Shenoy, Aman B Patel, David A Boas, Maria Angela Franceschini, Eric S Rosenthal. 2018. "Prolonged monitoring of cerebral blood flow and autoregulation with diffuse correlation spectroscopy in neurocritical care patients.." Neurophotonics, Volume 5, Issue 4:045005. https://doi.org/10.1117/1.NPh.5.4.045005
dc.identifier.issn2329-423X
dc.identifier.urihttps://hdl.handle.net/2144/37734
dc.description.abstractMonitoring of cerebral blood flow (CBF) and autoregulation are essential components of neurocritical care, but continuous noninvasive methods for CBF monitoring are lacking. Diffuse correlation spectroscopy (DCS) is a noninvasive diffuse optical modality that measures a CBF index ( CBF i ) in the cortex microvasculature by monitoring the rapid fluctuations of near-infrared light diffusing through moving red blood cells. We tested the feasibility of monitoring CBF i with DCS in at-risk patients in the Neurosciences Intensive Care Unit. DCS data were acquired continuously for up to 20 h in six patients with aneurysmal subarachnoid hemorrhage, as permitted by clinical care. Mean arterial blood pressure was recorded synchronously, allowing us to derive autoregulation curves and to compute an autoregulation index. The autoregulation curves suggest disrupted cerebral autoregulation in most patients, with the severity of disruption and the limits of preserved autoregulation varying between subjects. Our findings suggest the potential of the DCS modality for noninvasive, long-term monitoring of cerebral perfusion, and autoregulation.en_US
dc.description.sponsorshipR01 GM116177 - NIGMS NIH HHS; S10 RR019307 - NCRR NIH HHS; R21 NS094828 - NINDS NIH HHS; R00 HD083512 - NICHD NIH HHS; S10 RR023043 - NCRR NIH HHS; R21 NS093259 - NINDS NIH HHS; S10 RR023401 - NCRR NIH HHSen_US
dc.description.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233866/
dc.format.extent045005en_US
dc.languageeng
dc.relation.ispartofNeurophotonics
dc.rights© 2018 Society of Photo-Optical Instrumentation Engineers (SPIE)en_US
dc.subjectCerebral autoregulationen_US
dc.subjectCerebral blood flowen_US
dc.subjectDiffuse correlation spectroscopyen_US
dc.subjectNear-infrared spectroscopyen_US
dc.subjectNeurocritical careen_US
dc.subjectNeuromonitoringen_US
dc.subjectSubarachnoid hemorrhageen_US
dc.titleProlonged monitoring of cerebral blood flow and autoregulation with diffuse correlation spectroscopy in neurocritical care patientsen_US
dc.typeArticleen_US
dc.identifier.doi10.1117/1.NPh.5.4.045005
pubs.elements-sourcepubmeden_US
pubs.notesEmbargo: Not knownen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Engineeringen_US
pubs.organisational-groupBoston University, College of Engineering, Department of Biomedical Engineeringen_US
pubs.publication-statusPublisheden_US
dc.identifier.orcid0000-0002-6709-7711 (Boas, David A)
dc.description.oaversionPublished version
dc.identifier.mycv406868


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