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dc.contributor.authorAvci, Oguzhanen_US
dc.contributor.authorCampana, Maria I.en_US
dc.contributor.authorYurdakul, Celalettinen_US
dc.contributor.authorUnlu, M. Selimen_US
dc.date.accessioned2019-09-09T14:07:34Z
dc.date.available2019-09-09T14:07:34Z
dc.date.issued2017-02-20
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000394536700015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=6e74115fe3da270499c3d65c9b17d654
dc.identifier.citationOguzhan Avci, Maria I Campana, Celalettin Yurdakul, M Selim Unlu. 2017. "Pupil function engineering for enhanced nanoparticle visibility in wide-field interferometric microscopy." OPTICA, Volume 4, Issue 2, pp. 247 - 254 (8). https://doi.org/10.1364/OPTICA.4.000247
dc.identifier.issn2334-2536
dc.identifier.urihttps://hdl.handle.net/2144/37748
dc.description.abstractWide-field interferometric microscopy techniques have demonstrated their utility in sensing minute changes in the optical path length as well as visualization of sub-diffraction-limited nanoparticles. In this work, we demonstrate enhanced signal levels for nanoparticle detection by pupil function engineering in wide-field common-path interferometric microscopy. We quantify the improvements in nanoparticle signal achieved by novel optical filtering schemes, benchmark them against theory, and provide physical explanations for the signal enhancements. Our refined common-path interferometric microscopy technique provides an overall ten-fold enhancement in the visibility of low-index, non-resonant polystyrene nanospheres (𝑟∼25  nm), resulting in nearly 8% signal-to-background ratio. Our method can be a highly sensitive, low-cost, label-free, high-throughput platform for accurate detection and characterization of weakly scattering low-index nanoparticles with sizes ranging from several hundred down to a few tens of nanometers, covering nearly the entire size spectrum of biological particles.en_US
dc.description.sponsorshipI/UCRC Center for Biophotonic Sensors and Systems (CBSS). (I/UCRC Center for Biophotonic Sensors and Systems (CBSS))en_US
dc.format.extentp. 247 - 254en_US
dc.languageEnglish
dc.language.isoen_US
dc.publisherOPTICAL SOC AMERen_US
dc.relation.ispartofOPTICA
dc.subjectScience & technologyen_US
dc.subjectPhysical sciencesen_US
dc.subjectOpticsen_US
dc.subjectDigital detectionen_US
dc.subjectComplex mediaen_US
dc.subjectVirusesen_US
dc.subjectApertureen_US
dc.subjectExosomesen_US
dc.titlePupil function engineering for enhanced nanoparticle visibility in wide-field interferometric microscopyen_US
dc.typeArticleen_US
dc.description.versionPublished versionen_US
dc.identifier.doi10.1364/OPTICA.4.000247
pubs.elements-sourceweb-of-scienceen_US
pubs.notesEmbargo: Not knownen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Engineeringen_US
pubs.organisational-groupBoston University, College of Engineering, Department of Electrical & Computer Engineeringen_US
pubs.publication-statusPublisheden_US
dc.identifier.orcid0000-0002-8594-892X (Unlu, M Selim)
dc.identifier.mycv191845


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