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dc.contributor.authorCarp, S.A.en_US
dc.contributor.authorDai, G.P.en_US
dc.contributor.authorBoas, David A.en_US
dc.contributor.authorFranceschini, M.A.en_US
dc.contributor.authorKim, Y.R.en_US
dc.coverage.spatialUnited Statesen_US
dc.date2010-07-13
dc.date.accessioned2019-09-10T15:33:18Z
dc.date.available2019-09-10T15:33:18Z
dc.date.issued2010-08-10
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/21258489
dc.identifier.citationS.A. Carp, G.P. Dai, D.A. Boas, M.A. Franceschini, Y.R. Kim. 2010. "Validation of diffuse correlation spectroscopy measurements of rodent cerebral blood flow with simultaneous arterial spin labeling MRI; towards MRI-optical continuous cerebral metabolic monitoring.." Biomed Opt Express, Volume 1, Issue 2, pp. 553 - 565. https://doi.org/10.1364/BOE.1.000553
dc.identifier.issn2156-7085
dc.identifier.urihttps://hdl.handle.net/2144/37763
dc.description.abstractCerebral blood flow (CBF) during stepped hypercapnia was measured simultaneously in the rat brain using near-infrared diffuse correlation spectroscopy (DCS) and arterial spin labeling MRI (ASL). DCS and ASL CBF values agree very well, with high correlation (R=0.86, p< 10(-9)), even when physiological instability perturbed the vascular response. A partial volume effect was evident in the smaller magnitude of the optical CBF response compared to the MRI values (averaged over the cortical area), primarily due to the inclusion of white matter in the optically sampled volume. The 8.2 and 11.7 mm mid-separation channels of the multi-distance optical probe had the lowest partial volume impact, reflecting ~75 % of the MR signal change. Using a multiplicative correction factor, the ASL CBF could be predicted with no more than 10% relative error, affording an opportunity for real-time relative cerebral metabolism monitoring in conjunction with MR measurement of cerebral blood volume using super paramagnetic contrast agents.en_US
dc.description.sponsorshipR01 EB006385 - NIBIB NIH HHS; R01 EB001954 - NIBIB NIH HHS; R01 NS057476 - NINDS NIH HHS; P41 RR014075 - NCRR NIH HHS; R01 HD042908-07 - NICHD NIH HHS; R01 EB002066 - NIBIB NIH HHS; R01 HD042908-06 - NICHD NIH HHS; R01 HD042908 - NICHD NIH HHSen_US
dc.format.extent553 - 565en_US
dc.languageeng
dc.relation.ispartofBiomed Opt Express
dc.rights© 2010 Optical Society of America. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modifications of the content of this paper are prohibited.en_US
dc.subjectOpticsen_US
dc.subjectCerebral blood flowen_US
dc.titleValidation of diffuse correlation spectroscopy measurements of rodent cerebral blood flow with simultaneous arterial spin labeling MRI; towards MRI-optical continuous cerebral metabolic monitoring.en_US
dc.typeArticleen_US
dc.description.versionPublished versionen_US
dc.identifier.doi10.1364/BOE.1.000553
pubs.elements-sourcepubmeden_US
pubs.notesEmbargo: Not knownen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Engineeringen_US
pubs.organisational-groupBoston University, College of Engineering, Department of Biomedical Engineeringen_US
pubs.publication-statusPublished onlineen_US
dc.identifier.orcid0000-0002-6709-7711 (Boas, DA)
dc.identifier.mycv241827


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