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dc.contributor.authorPhillip, Dorteen_US
dc.contributor.authorIversen, Helle K.en_US
dc.contributor.authorSchytz, Henrik W.en_US
dc.contributor.authorSelb, Julietteen_US
dc.contributor.authorBoas, David A.en_US
dc.contributor.authorAshina, Messouden_US
dc.coverage.spatialSwitzerlanden_US
dc.date2013-12-03
dc.date.accessioned2019-09-18T13:10:59Z
dc.date.available2019-09-18T13:10:59Z
dc.date.issued2013
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/24379801
dc.identifier.citationPhillip D, Iversen HK, Schytz HW, Selb J, Boas DA and Ashina M (2013) Altered low frequency oscillations of cortical vessels in patients with cerebrovascular occlusive disease – a NIRS study. Front. Neurol. 4:204. https://doi.org/10.3389/fneur.2013.00204
dc.identifier.issn1664-2295
dc.identifier.urihttps://hdl.handle.net/2144/37834
dc.description.abstractAnalysis of cerebral autoregulation by measuring spontaneous oscillations in the low frequency spectrum of cerebral cortical vessels might be a useful tool for assessing risk and investigating different treatment strategies in carotid artery disease and stroke. Near infrared spectroscopy (NIRS) is a non-invasive optical method to investigate regional changes in oxygenated (oxyHb) and deoxygenated hemoglobin (deoxyHb) in the outermost layers of the cerebral cortex. In the present study we examined oxyHb low frequency oscillations, believed to reflect cortical cerebral autoregulation, in 16 patients with both symptomatic carotid occlusive disease and cerebral hypoperfusion in comparison to healthy controls. Each hemisphere was examined with two NIRS channels using a 3 cm source detector distance. Arterial blood pressure (ABP) was measured via a finger plethysmograph. Using transfer function analysis ABP-oxyHb phase shift and gain as well as inter-hemispheric phase shift and amplitude ratio were assessed. We found that inter-hemispheric amplitude ratio was significantly altered in hypoperfusion patients compared to healthy controls (P = 0.010), because of relatively lower amplitude on the hypoperfusion side. The inter-hemispheric phase shift showed a trend (P = 0.061) toward increased phase shift in hypoperfusion patients compared to controls. We found no statistical difference between hemispheres in hypoperfusion patients for phase shift or gain values. There were no differences between the hypoperfusion side and controls for phase shift or gain values. These preliminary results suggest an impairment of autoregulation in hypoperfusion patients at the cortical level detected by NIRS.en_US
dc.description.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864103/
dc.languageeng
dc.relation.ispartofFront Neurol
dc.rightsCopyright: © 2013 Phillip, Iversen, Schytz, Selb, Boas and Ashina. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectDoppleren_US
dc.subjectCarotid artery diseaseen_US
dc.subjectCerebral autoregulationen_US
dc.subjectHypoperfusionen_US
dc.subjectLow frequency oscillationsen_US
dc.subjectNear infrared spectroscopyen_US
dc.subjectStrokeen_US
dc.subjectNeurosciencesen_US
dc.subjectClinical sciencesen_US
dc.subjectPsychologyen_US
dc.titleAltered low frequency oscillations of cortical vessels in patients with cerebrovascular occlusive disease – a NIRS studyen_US
dc.typeArticleen_US
dc.description.versionPublished versionen_US
dc.identifier.doi10.3389/fneur.2013.00204
pubs.elements-sourcepubmeden_US
pubs.notesEmbargo: Not knownen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Engineeringen_US
pubs.organisational-groupBoston University, College of Engineering, Department of Biomedical Engineeringen_US
pubs.publication-statusPublished onlineen_US
dc.identifier.orcid0000-0002-6709-7711 (Boas, David A)
dc.description.oaversionPublished version
dc.identifier.mycv241798


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Copyright: © 2013 Phillip, Iversen, Schytz, Selb, Boas and Ashina. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Except where otherwise noted, this item's license is described as Copyright: © 2013 Phillip, Iversen, Schytz, Selb, Boas and Ashina. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.