Optimal path to epigenetic switching
Roma, D. M.
O'Flanagan, R. A.
Ruckenstein, A. E.
Sengupta, A. M.
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Citation (published version)D.M. Roma, R.A. O'Flanagan, A.E. Ruckenstein, A.M. Sengupta, R. Mukhopadhyay. 2005. "Optimal path to epigenetic switching." PHYSICAL REVIEW E, Volume 71, Issue 1, pp. ? - ? (5). https://doi.org/10.1103/PhysRevE.71.011902
We use large deviation methods to calculate rates of noise-induced transitions between states in multistable genetic networks. We analyze a synthetic biochemical circuit, the toggle switch, and compare the results to those obtained from a numerical solution of the master equation.