Brain cell injury: metabolic dysfunction in ischemia and hypoxia
Salvadore, Christopher P.
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A sequence of biochemical events responsible for the destruction of brain cells during oxygen deprivation has been proposed based on available experimental evidence reviewed in the text. Oxygen deficiency results in a diminished p02 within the cell, resulting in inhibition of the electron transport chain and depletion of ATP pools. The decrease in cellular energy charge mediates a reduction in phospholipid synthesis, as well as the collapse of ionic gradients across the plasma and organelle membranes. Highly elevated levels of cytosolic Ca++ follow, activating membrane bound phospholipases which progressively deplete the membrane of its phospholipids. Membrane structure becomes severely compromised, resulting in loss of function. Cell death ensues.
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