The effect of parathyroidectomy on the ability of decalcified allogenic bone grafts to stimulate new bone formation in rats

Abstract

The purpose of these experiments was to determine the effect of parathyroidectomy on the ability of decalcified allogenic bone grafts to stimulate new bone formation in rats. Experimental fracture gaps in the rat tibia were produced by the removal of a piece of bone four to five millimeters in length. Decalcified allogenic bone grafts were placed into the gap for periods up to eight weeks. Results showed that essentially equivalent degrees of mineralization were realized by both intact and parathyroidectomized animal undergoing decalcified allogenic bone grafts. It is concluded that the presence or absence of parathyroid hormone either doesn’t relate to the graft situation or exists on such a level that its presence or absence is not relevant in this process.