Histatin degradation by oral fluid proteases : temporal cleavage patterns and enzyme specificities
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Histatins are a family of small histidine-rich salivary proteins secreted predominantly by the parotid and submandibular glands. Histatins exhibits multiple properties deemed important for oral health, such as antimicrobial and wound-healing capacities. It is well known that histatins are proteolytically cleaved once they undergo the transition from the sterile salivary glandular environment to the non-sterile oral cavity. The proteolytic cascade and the kinds of proteases involved in their degredation in whole saliva remain largely unknown. In view of the anticipated functional implications of histatin degradation, the aim of this project is to shed light on the proteolytic mechanisms of fluid proteases towards histatins. [Truncated]
PLEASE NOTE: This work is protected by copyright. Downloading is restricted to the BU community: please click Download and log in with a valid BU account to access. If you are the author of this work and would like to make it publicly available, please contact firstname.lastname@example.org.Thesis (D.Sc.)--Boston University, Goldman School of Dental Medicine, 2008 (Dept. of Periodontology and Oral Biology).Includes bibliographical references: leaves 113-121.
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