Effects of dietary ascorbic acid, lipids and bioflavonoids on selected hepatic biochemical parameters in rats
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The research in this thesis set out to study a postulated relationship between dietary factors and lipid or glycoprotein metabolism. Two experimental trails were carried out: In the first trial, the effects of diets supplemented with a mixture of bioflavonoids (rutin, naringin, and hes- peridin), with and without ascorbic acid, were tested. The ascorbic acid and bioflavonoid group (CB) showed a significant increasein total liver weights, but a decrease in the bound hexosamines after 90 days of dietary treatment. In the second trial, the effects of a high lipid diet (containing coconut oil and cholesterol), with and without naringenin, were tested. Again, liver weights were significantly increased following the feeding of the high lipid diet. Furthermore, elevations in liver total lipids (both neutral and polar) were observed. Among the neutral lipids, the cholesterol esters and triglycerides were significantly increased. Among the polar lipids, lysophosphatidyl cho|ine, sphingo-myelin, phophatidyl choline, phosphatidyl serine and inositol, phosphatidyl ethanolamine, and phosphatidic acid were all elevated following the feeding of the high lipid diet. When naringenin was included in this diet, the lipids studied were decreased to levels approaching, in some cases, those seen in the control diet. The feeding of a high lipid diet also resulted in significant increases in the total acid-soluble glycoproteins of the liver; this phenomenon was accompanied by a relative decrease in the bound fucose levels. Among the total acid-insoluble glycoproteins, the bound hexosamines, fucose, and sialic acid levels were all significantly increased. The aim of this research had been to determine whether certain bioflavonoids, particularly naringenin, influence hepatic events. On the basis of our results, two interpretations were considered. The first question was whether certain bioflavonoids affect hepatic events, particularly the integrity of membranes. In this light, a similarity between the structure of certain bioflavonoids and sterols was taken into account. Also, the possibility that bioflavonoids affect the absorption of lipids was also considered. In any event, the data clearly shows that bioflavonoids do influence lipid metabolism and that such an influence can offer another approach in the study of the biochemical sequence of events related to disease states, including extra-hepatic tissues. The author's ultimate aim is to develop an experimental model to study further the effects of bioflavonoids and lipids on the pathogenesis of periodontal disease. This aim was inspired by earlier studies in this laboratory that have demonstrated the efficacy of dietary bioflavonoids in the prevention of periodontitis in the rat.
PLEASE NOTE: This work is protected by copyright. Downloading is restricted to the BU community: please click Download and log in with a valid BU account to access. If you are the author of this work and would like to make it publicly available, please contact email@example.com.Thesis (D.Sc.D.)--Boston University, Henry M. Goldman School of Graduate Dentistry, 1984, (Nutritional Sciences)Bibliography: leaves 125-159.
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