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    Recent examples of α-ketoglutarate-dependent mononuclear non-haem iron enzymes in natural product biosyntheses

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    Date Issued
    2018-08-15
    Publisher Version
    10.1039/c7np00067g
    Author(s)
    Gao, Shu-Shan
    Naowarojna, Nathchar
    Cheng, Ronghai
    Liu, Xueting
    Liu, Pinghua
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    Permanent Link
    https://hdl.handle.net/2144/38375
    Version
    Accepted manuscript
    Citation (published version)
    Shu-Shan Gao, Nathchar Naowarojna, Ronghai Cheng, Xueting Liu, Pinghua Liu. 2018. "Recent examples of α-ketoglutarate-dependent mononuclear non-haem iron enzymes in natural product biosyntheses.." Nat Prod Rep, Volume 35, Issue 8, pp. 792 - 837. https://doi.org/10.1039/c7np00067g
    Abstract
    Covering: up to 2018 α-Ketoglutarate (αKG, also known as 2-oxoglutarate)-dependent mononuclear non-haem iron (αKG-NHFe) enzymes catalyze a wide range of biochemical reactions, including hydroxylation, ring fragmentation, C-C bond cleavage, epimerization, desaturation, endoperoxidation and heterocycle formation. These enzymes utilize iron(ii) as the metallo-cofactor and αKG as the co-substrate. Herein, we summarize several novel αKG-NHFe enzymes involved in natural product biosyntheses discovered in recent years, including halogenation reactions, amino acid modifications and tailoring reactions in the biosynthesis of terpenes, lipids, fatty acids and phosphonates. We also conducted a survey of the currently available structures of αKG-NHFe enzymes, in which αKG binds to the metallo-centre bidentately through either a proximal- or distal-type binding mode. Future structure-function and structure-reactivity relationship investigations will provide crucial information regarding how activities in this large class of enzymes have been fine-tuned in nature.
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    • CAS: Chemistry: Scholarly Papers [120]
    • BU Open Access Articles [3727]


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