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dc.contributor.authorBaumann, Cory W.en_US
dc.contributor.authorKwak, Dongminen_US
dc.contributor.authorThompson, LaDora V.en_US
dc.date.accessioned2019-11-05T20:06:31Z
dc.date.available2019-11-05T20:06:31Z
dc.date.issued2018-12-01
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000454633200037&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=6e74115fe3da270499c3d65c9b17d654
dc.identifier.citationCory W Baumann, Dongmin Kwak, LaDora V Thompson. 2018. "Assessing onset, prevalence and survival in mice using a frailty phenotype." Aging, Volume 10, Issue 12, pp. 4042 - 4053 (12). https://doi.org/10.18632/aging.101692
dc.identifier.issn1945-4589
dc.identifier.urihttps://hdl.handle.net/2144/38424
dc.description.abstractLittle is known whether frailty assessments in mice are capable of distinguishing important characteristics of the frailty syndrome. The goals of this study were to identify the onset and the prevalence of frailty across the lifespan and to determine if a frailty phenotype predicts mortality. Body weight, walking speed, strength, endurance and physical activity were assessed in male C57BL/6 mice every three months starting at 14 months of age. Mice that fell in the bottom 20% for walking speed, strength, endurance and physical activity, and in the top 20% for body weight were considered to have a positive frailty marker. The onset of frailty occurred at 17 months, and represented only 3.5% of the mouse cohort. The percentage of frail mice increased with age until basically every mouse was identified as frail. Frail, pre-frail, and non-frail mice had mean survival ages of 27, 29 and 34 months, respectively. In closing, frail mice lack resilience; in that, multiple tissue/organ systems may deteriorate at an accelerated rate and ultimately lead to early mortality when compared to non-frail mice. Identifying the onset and prevalence of frailty, in addition to predicting mortality, has potential to yield information about several aging processes.en_US
dc.description.sponsorshipThis work was supported by the National Institutes of Health (T32-AG029796 to L.V.T & C.W.B and T32-AR007612 to C.W.B) and Travis Roy Endowed Professorship (to L.V.T). (T32-AG029796 - National Institutes of Health; T32-AR007612 - National Institutes of Health)en_US
dc.format.extent4042 - 4053 (12)en_US
dc.languageEnglish
dc.publisherIMPACT JOURNALS LLCen_US
dc.relation.ispartofAging
dc.rightsCopyright: Baumann et al. This is an open‐access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/
dc.subjectLife sciences & biomedicineen_US
dc.subjectCell biologyen_US
dc.subjectGeriatrics & gerontologyen_US
dc.subjectAgingen_US
dc.subjectDiseaseen_US
dc.subjectFunctionen_US
dc.subjectMuscleen_US
dc.subjectObesityen_US
dc.subjectPhysiologyen_US
dc.subjectDevelopmental biologyen_US
dc.titleAssessing onset, prevalence and survival in mice using a frailty phenotypeen_US
dc.typeArticleen_US
dc.description.versionPublished versionen_US
dc.identifier.doi10.18632/aging.101692
pubs.elements-sourceweb-of-scienceen_US
pubs.notesEmbargo: No embargoen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Health & Rehabilitation Sciences: Sargent Collegeen_US
pubs.organisational-groupBoston University, College of Health & Rehabilitation Sciences: Sargent College, Physical Therapy and Athletic Trainingen_US
pubs.publication-statusPublisheden_US
dc.identifier.mycv408045


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Copyright: Baumann et al. This is an open‐access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Except where otherwise noted, this item's license is described as Copyright: Baumann et al. This is an open‐access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.