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dc.contributor.advisorMoussavi, Minaen_US
dc.contributor.advisorOffner, Gwynnethen_US
dc.contributor.authorMukerji, Shivalien_US
dc.date.accessioned2019-12-04T18:54:32Z
dc.date.available2019-12-04T18:54:32Z
dc.date.issued2019
dc.identifier.urihttps://hdl.handle.net/2144/38668
dc.description.abstractParkinson’s disease (PD) is a devastating neurodegenerative disease and the second most prevalent after Alzheimer’s disease. The most characteristic hallmark of Parkinson’s is the presence of Lewy Bodies, clumps of aggregated α-synuclein protein, in the Substantia Nigra. While much has been said and theorized about α-synuclein, mitochondrial dysregulation in neurons of Parkinson’s patients is an equally important consideration due to the role that the mitochondria plays in supplying neurons with their energy needs through ATP. C. elegans is a non-vertebrate animal often used to study aging and neurodegenerative disease due to its simple, well characterized genome. This literature review aims to outline the genetic and some environmental factors that cause mitochondrial dysregulation leading to the progressive neurodegeneration witnessed in Parkinson’s, as modeled in C. elegans. Through a select review of studies done on C. elegans homolog of genes associated with mitochondrial function, this review aims to elucidate the mechanism by which each mutation not only causes the deficits seen in PD on its own but also how it interacts with other genes to worsen or alleviate symptoms. Ultimately, understanding these pathways and mechanism will be crucial to discovering and creating new therapeutic treatments and targets.en_US
dc.language.isoen_US
dc.subjectNeurosciencesen_US
dc.subjectC. elegansen_US
dc.subjectL-DOPAen_US
dc.subjectMitochondrial dysregulationen_US
dc.subjectOxidative stressen_US
dc.subjectParkinson's diseaseen_US
dc.titleMitochondrial dysfunction in C. elegans model of Parkinson's diseaseen_US
dc.typeThesis/Dissertationen_US
dc.date.updated2019-10-10T01:03:00Z
etd.degree.nameMaster of Scienceen_US
etd.degree.levelmastersen_US
etd.degree.disciplineMedical Sciencesen_US
etd.degree.grantorBoston Universityen_US


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