The use of lightchemically-hardened poly-methyl-methacrylate, poly-hydroxy-ethyl-methacrylate and calcium hydroxide graft material in combination with polyanhydride around implants immediately placed into extraction sockets :
Ghattas, Mazen Souhail
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Although immediate implant placement has been demonstrated to be as reliable as traditional surgical techniques, several problems relating to primary stability, consistent management of soft tissue, and bone healing on implant surfaces at the coronal level where a wide gap between bone and implant was present at the implantation time, have been reported. The search for suitable bone substitute materials has intensified over the years due to the shortcomings of autografts, mainly donor site morbidity and limited available bone volume. The aim of the present “proof of concept study” was to evaluate the impact of light/chemically hardened poly-methyl-methacrylate, poly-ethyl-methacrylate and calcium hydroxide composite graft in combination with polyanhydride (PPCH + PA) on immediate implant stability and function and the ability to augment extraction sockets in a mini-pig model. Four mandibular premolar teeth and one molar tooth per quadrant were extracted; a total of 48 implants and 60 sockets were randomly assigned to receive one of the four treatments: 1) augmentation with PPCH + PA; 2) augmentation with PA; 3) augmentation with PPCH and 4) no augmentation. At 12 weeks, block sections were obtained. Implant stability was measured using Periotron at 2, 6 and 12 weeks. Soft tissue probing, and radiological evaluations were performed to detect any soft tissue reaction and bone resorption around implants. Implant-bone interface was examined with mechanical test using lnstron followed by a scanning electron microscope evaluations, microcomputed tomography (microCT) and histopathological evaluations. The resected blocks were demineralized, and stained with either hematoxylin and eosin or Masson’s trichrome for evaluation of bone and collagen formation and histomorphometric measurements. The results of the present study demonstrate that socket preservation and augmentation of implants after immediate implant placement promoted bone formation and supported the stability of the implants. [TRUNCATED]
Dissertation (MSD) --Boston University, Henry M. Goldman School of Dental Medicine, 2010 (Department of Periodontology and Oral Biology).Includes bibliographic references: leaves 93-109.
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