In vivo study of biphasic bioactive glasses
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Objectives: This study investigated the biphasic bioactive glass, which contained standard melt-derived bioactive glass (BG) and sol-gel glass (SG), by assessing the in vivo effects on bone formation, bone strength, material degradation and mineralization in the implanted sites. Methods: Fifty-six rabbits were included in this random blind study to provide a total of l112 surgical sites for four different groups: two groups of biphasic bioactive glasses with various compositions (SG1 , SG2), Bioglass (BG), and the control. The materials were placed in 7 mm diameter defects created at the mesial ends of the tibia. No material was placed in the empty defects of the controls. Each material group was divided into four time periods, three, six, twelve and twenty-four weeks. Seven surgical sites per time period were used for each group. After the animals were sacrificed, each sample was examined by radiograph, histology, three-point bending test, and an energy dispersive spectrum (EDS) to evaluate the materials resorption and the osteogeneration. Results: The SG1 showed highest resorption in the histology at 6 weeks (ANOVA, P[less than]0.05), and at the same time period the amount of bone formation was similar to SG2 and BG group. The SG1 group had the highest mechanical strength of the new bone at the end of the study. From the EDS the SG1 groups yielded a higher mineralization of newly formed bone tissue in the periphery than the other groups at 3 weeks (ANOVA p[less than]0.01). Conclusion: The material, SG1, accelerated bone repair, because it was quickly resorbed by the host, generated high amount of mineralization around the implanted area at the third week, and led to a higher mechanical strength of the new bone at the end of 24 weeks.
Thesis (D.Sc.)--Boston University, Henry M. Goldman School of Dental Medicine, 2005.Includes bibliographical references: leaves 182-192.
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