Effects of ascorbic acid in a diet high in sucrose on the tongue, oral mucosa and muscular tissue in the prepubertal rat
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Our aim was to determine the effects of ascorbic acid supplementation in a diet high in sucrose (suboptimal in protein) on the tongue, oral mucosa and other selected tissues in the rapidly growing rat. After a period of two week, a diet high in sucrose resulted in a significant decrease in DNA concentrations in heart muscle; this decrease was found to be reversed if ascorbic acid was included; on the other hand the protein concentrations of heart muscle were lower, suggesting that ascorbic acid favors either an increased turnover or decreased synthesis of total protein.In femoral muscle, we found a significant decrease in the protein bound hexoses among the rats fed the high sucrose diet; this phenomenon was reversed if ascorbic acid was included in such a diet; apparently, ascorbic acid tended to 'normalize' the concentration of protein bound hexoses in this tissue. In the tongue, the fucose to protein ratio was decreased in the control diet group treated with ascorbic acid; no such effect was observed in the rats fed the experimental diet with ascorbic acid. Our data favors an interpretation that the ingestion of diet high in sucrose apparently is ameliorated, in some instances, by the ascorbic acid treatment. The chemical differences seen offer an approach toward designing specific experiments to determine the actual biochemical events in oral tissues. We discussed the relationship between the increased consumption of sucrose with the view of ascorbic acid needs. Such knowledge is important in dealing with populaulations c○nsuming foods high in sucrose. Thee consequences in related metabolic disorders were also discussed.
PLEASE NOTE: This work is protected by copyright. Downloading is restricted to the BU community: please click Download and log in with a valid BU account to access. If you are the author of this work and would like to make it publicly available, please contact firstname.lastname@example.org.Thesis (M.Sc.D.)--Boston University, Henry M. Goldman School of Graduate Dentistry, 1981 (Pedodontics)Bibliography: leaves 42-51.
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