Possible cytotoxic effects of alloys used for cast dental restorations
Hitti, Fuad Raymond
Duval, Moema Silva e
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The objectives of this study were a) to examine the potential cytotoxicity of extracts prepared from 14 different dental materials using the chromium-51 release and lymphocyte compatibility assays and b) to assess the relative sensitivities of these two in vitro cytotoxicity test systems. A comparison of the results of the chromium release and the lymphocte compatibility assays indicate that the lymphocyte assay is a more sensitive screen for potential cytotoxic agents. In this study samples of Option, Athenium and Ceral exhibited concentration-related cytotoxic responses in the human lymphocyte compatibility assay, but did not influence chromium release under comparable experimental conditions. Two of the sample extracts which proved to be cytotoxic in the lymphocyte compatibility assay (Option and Athenium)contained detectable levels of copper. The third cytotoxic extract, obtained from sample number 9 (Ceral) was found to contain a high level of nickel.
PLEASE NOTE: This work is protected by copyright. Downloading is restricted to the BU community: please click Download and log in with a valid BU account to access. If you are the author of this work and would like to make it publicly available, please contact firstname.lastname@example.org.Thesis (M.Sc.D.)--Boston University, Henry M. Goldman School of Graduate Dentistry, 1984, (Prosthodontics)Bibliography: leaves -
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