The effect of corticotomy and orthodontic tooth movement on bone remineralization as measured by micro-computed tomography as a function of time
Lowe, Zachton J Eno
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The primary goal of this study was to determine the changes in bone mineralization over time when corticotomy was used in conjunction with orthodontic treatment. Bone mineralization and volume was measured using micro-computed tomography. Corticotomy along with orthodontic movement was performed in 28 rats using a split mouth design as the control. Bone was characterized as either low density (585-960 mg/cm3) or high density (960 mg/cm3) and analyzed independently and together. It was found that the majority of statistically significant changes were found in the low-density bone. In the low-density bone, the volume and mineralization changed statistically when compared with the control (p[less than] 2.6E-10 and 1.3E-05, respectively). It was seen statistically that the volume of low density bone continued to decrease over the first couple weeks and then held fairly steady throughout the rest of orthodontic movement through week 6 (p[less than]0.0044). These data suggest that the majority of the change caused by the corticotomy procedure is in the lower density trabecular bone as opposed to the higher density cortical bone, which drives the increase in orthodontic speed and bone turnover as a significant factor.
PLEASE NOTE: This work is protected by copyright. Downloading is restricted to the BU community: please click Download and log in with a valid BU account to access. If you are the author of this work and would like to make it publicly available, please contact firstname.lastname@example.org.Thesis (MSD) --Boston University, Goldman School of Dental Medicine, 2009 (Department of Orthodontics and Dentofacial Orthopedics).Includes bibliography: leaves 43-46.
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