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dc.contributor.authorKaiser, Jarreden_US
dc.contributor.authorAllaire, B.en_US
dc.contributor.authorFein, Paulen_US
dc.contributor.authorLu, Darleneen_US
dc.contributor.authorJarraya, Muhammaden_US
dc.contributor.authorGuermazi, Alien_US
dc.contributor.authorDemissie, Serkalemen_US
dc.contributor.authorSamelson, Elizabethen_US
dc.contributor.authorBouxsein, Maryen_US
dc.contributor.authorMorgan, Eliseen_US
dc.date.accessioned2020-01-21T15:13:18Z
dc.date.available2020-01-21T15:13:18Z
dc.date.issued2018-11-12
dc.identifier.citationJarred Kaiser, B. Allaire, Paul Fein, Darlene Lu, Muhammad Jarraya, Ali Guermazi, Serkalem Demissie, Elizabeth Samelson, Mary Bouxsein, Elise Morgan. 2018. "Correspondence between bone mineral density and intervertebral disc degeneration across age and sex." Archives of Osteoporosis, Volume 13, Issue 1, pp. 123 - 123. https://doi.org/10.1007/s11657-018-0538-1
dc.identifier.issn1862-3514
dc.identifier.urihttps://hdl.handle.net/2144/39123
dc.description.abstractThe distribution of bone tissue within the vertebra can modulate vertebral strength independently of average density and may change with age and disc degeneration. Our results show that the age-associated decrease in bone density is spatially non-uniform and associated with disc health, suggesting a mechanistic interplay between disc and vertebra. PURPOSE: While the decline of bone mineral density (BMD) in the aging spine is well established, the extent to which age influences BMD distribution within the vertebra is less clear. Measures of regional BMD (rBMD) may improve predictions of vertebral strength and suggest how vertebrae might adapt with intervertebral disc degeneration. Thus, we aimed to assess how rBMD values were associated with age, sex, and disc height loss (DHL). METHODS: We measured rBMD in the L3 vertebra of 377 participants from the Framingham Heart Study (41-83 years, 181 M/196 F). Integral (Int.BMD) and trabecular BMD (Tb.BMD) were measured from QCT images. rBMD ratios (anterior/posterior, superior/mid-transverse, inferior/mid-transverse, and central/outer) were calculated from the centrum. A radiologist assigned a DHL severity score to adjacent intervertebral discs (L2-L3 and L3-L4). RESULTS: Int.BMD and Tb.BMD were both associated with age, though the decrease across age was greater in women (Int.BMD, - 2.6 mg/cm3 per year; Tb.BMD, - 2.6 mg/cm3 per year) than men (Int.BMD, - 0.5 mg/cm3 per year; Tb.BMD, - 1.2 mg/cm3 per year). The central/outer (- 0.027/decade) and superior/mid-transverse (- 0.018/decade) rBMD ratios were negatively associated with age, with similar trends in men and women. Higher Int.BMD or Tb.BMD was associated with increased odds of DHL after adjusting for age and sex. Low central/outer ratio and high anterior/poster and superior/mid-transverse ratios were also associated with increased odds of DHL. CONCLUSIONS: Our results indicate that the distribution of bone within the L3 vertebra is different across age, but not between sexes, and is associated with disc degeneration.en_US
dc.format.extentp. 123en_US
dc.language.isoen_US
dc.publisherSpringer (part of Springer Nature)en_US
dc.relation.ispartofArchives of Osteoporosis
dc.subjectAgingen_US
dc.subjectVertebral BMDen_US
dc.subjectintervertebral disc degenerationen_US
dc.subjectComplementary and alternative medicineen_US
dc.titleCorrespondence between bone mineral density and intervertebral disc degeneration across age and sexen_US
dc.typeArticleen_US
dc.description.versionAccepted manuscripten_US
dc.identifier.doi10.1007/s11657-018-0538-1
dc.description.embargo2020-05-12
pubs.elements-sourcemanual-entryen_US
pubs.notesEmbargo: 18 monthsen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Engineeringen_US
pubs.organisational-groupBoston University, College of Engineering, Department of Mechanical Engineeringen_US
pubs.publication-statusPublisheden_US
dc.identifier.mycv456714


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