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dc.contributor.authorEllard, Kristen K.en_US
dc.contributor.authorBernstein, Emily E.en_US
dc.contributor.authorHearing, Caseyen_US
dc.contributor.authorBaek, Ji Hyunen_US
dc.contributor.authorSylvia, Louisa G.en_US
dc.contributor.authorNierenberg, Andrew A.en_US
dc.contributor.authorBarlow, David H.en_US
dc.contributor.authorDeckersbach, Thiloen_US
dc.date.accessioned2020-01-24T16:54:36Z
dc.date.available2020-01-24T16:54:36Z
dc.date.issued2017-09-01
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000406463600029&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=6e74115fe3da270499c3d65c9b17d654
dc.identifier.citationKristen K Ellard, Emily E Bernstein, Casey Hearing, Ji Hyun Baek, Louisa G Sylvia, Andrew A Nierenberg, David H Barlow, Thilo Deckersbach. 2017. "Transdiagnostic treatment of bipolar disorder and comorbid anxiety using the Unified Protocol for Emotional Disorders: A pilot feasibility and acceptability trial." Journal Of Affective Disorders, Volume 219, pp. 209 - 221. https://doi.org/10.1016/j.jad.2017.05.011
dc.identifier.issn0165-0327
dc.identifier.issn1573-2517
dc.identifier.urihttps://hdl.handle.net/2144/39159
dc.description.abstractBACKGROUND Comorbid anxiety in bipolar disorder (BD) is associated with greater illness severity, reduced treatment response, and greater impairment. Treating anxiety in the context of BD is crucial for improving illness course and outcomes. The current study examined the feasibility, acceptability and preliminary efficacy of the Unified Protocol (UP), a transdiagnostic cognitive behavioral therapy, as an adjunctive treatment to pharmacotherapy for BD and comorbid anxiety disorders. METHODS Twenty-nine patients with BD and at least one comorbid anxiety disorder were randomized to pharmacotherapy treatment-as-usual (TAU) or TAU with 18 sessions of the UP (UP+TAU). All patients completed assessments every four weeks to track symptoms, functioning, emotion regulation and temperament. Linear mixed-model regressions were conducted to track symptom changes over time and to examine the relationship between emotion-related variables and treatment response. RESULTS Satisfaction ratings were equivalent for both treatment groups. Patients in the UP+TAU group evidenced significantly greater reductions over time in anxiety and depression symptoms (Cohen's d's>0.80). Baseline levels of neuroticism, perceived affective control, and emotion regulation ability predicted magnitude of symptom change for the UP+TAU group only. Greater change in perceived control of emotions and emotion regulation skills predicted greater change in anxiety related symptoms. LIMITATIONS This was a pilot feasibility and acceptability trial; results should be interpreted with caution. CONCLUSIONS Treatment with the UP+TAU was rated high in patient satisfaction, and resulted in significantly greater improvement on indices of anxiety and depression relative to TAU. This suggests that the UP may be a feasible treatment approach for BD with comorbid anxiety.en_US
dc.description.sponsorshipThis work was supported by a Postdoctoral National Research Service Award from the National Institutes of Health [F32 MH098490] to K. Ellard. (F32 MH098490 - Postdoctoral National Research Service Award from the National Institutes of Health)en_US
dc.format.extent209 - 221 (13)en_US
dc.languageEnglish
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofJOURNAL OF AFFECTIVE DISORDERS
dc.subjectLife sciences & biomedicineen_US
dc.subjectClinical neurologyen_US
dc.subjectPsychiatryen_US
dc.subjectNeurosciences & neurologyen_US
dc.subjectBipolar disorderen_US
dc.subjectAnxiety disordersen_US
dc.subjectTransdiagnosticen_US
dc.subjectCognitive behavioral therapyen_US
dc.subjectEmotion regulationen_US
dc.subjectRandomized controlled trialen_US
dc.subjectAdulten_US
dc.subjectAntipsychotic agentsen_US
dc.subjectAnxietyen_US
dc.subjectBipolar disorderen_US
dc.subjectClinical protocolsen_US
dc.subjectCognitive behavioral therapyen_US
dc.subjectCombined modality therapyen_US
dc.subjectComorbidityen_US
dc.subjectEmotionsen_US
dc.subjectFeasibility studiesen_US
dc.subjectFemaleen_US
dc.subjectHumansen_US
dc.subjectMaleen_US
dc.subjectMiddle ageden_US
dc.subjectPatient satisfactionen_US
dc.subjectPilot projectsen_US
dc.subjectTreatment outcomeen_US
dc.subjectPatient satisfactionen_US
dc.subjectMedical and health sciencesen_US
dc.subjectPsychology and cognitive sciencesen_US
dc.titleTransdiagnostic treatment of bipolar disorder and comorbid anxiety using the Unified Protocol for Emotional Disorders: A pilot feasibility and acceptability trialen_US
dc.typeArticleen_US
dc.description.versionAccepted manuscripten_US
dc.identifier.doi10.1016/j.jad.2017.05.011
pubs.elements-sourceweb-of-scienceen_US
pubs.notesEmbargo: No embargoen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Arts & Sciencesen_US
pubs.organisational-groupBoston University, College of Arts & Sciences, Department of Psychological & Brain Sciencesen_US
pubs.publication-statusPublisheden_US
dc.identifier.mycv197609


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