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    Towards minimally-invasive, quantitative assessment of chronic kidney disease using optical spectroscopy

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    This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
    Date Issued
    2019-05-09
    Publisher Version
    10.1038/s41598-019-43684-8
    Author(s)
    Belghasem, Mostafa E.
    A'amar, Ousama
    Roth, Daniel
    Walker, Joshua
    Arinze, Nkiruka
    Richards, Sean M.
    Francis, Jean M.
    Salant, David J.
    Chitalia, Vipul C.
    Bigio, Irving J.
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    Permanent Link
    https://hdl.handle.net/2144/39198
    Version
    Accepted manuscript
    Citation (published version)
    Mostafa E Belghasem, Ousama A'amar, Daniel Roth, Joshua Walker, Nkiruka Arinze, Sean M Richards, Jean M Francis, David J Salant, Vipul C Chitalia, Irving J Bigio. 2019. "Towards minimally-invasive, quantitative assessment of chronic kidney disease using optical spectroscopy.." Sci Rep, Volume 9, Issue 1, pp. 7168 - ?. https://doi.org/10.1038/s41598-019-43684-8
    Abstract
    The universal pathologic features implicated in the progression of chronic kidney disease (CKD) are interstitial fibrosis and tubular atrophy (IFTA). Current methods of estimating IFTA are slow, labor-intensive and fraught with variability and sampling error, and are not quantitative. As such, there is pressing clinical need for a less-invasive and faster method that can quantitatively assess the degree of IFTA. We propose a minimally-invasive optical method to assess the macro-architecture of kidney tissue, as an objective, quantitative assessment of IFTA, as an indicator of the degree of kidney disease. The method of elastic-scattering spectroscopy (ESS) measures backscattered light over the spectral range 320-900 nm and is highly sensitive to micromorphological changes in tissues. Using two discrete mouse models of CKD, we observed spectral trends of increased scattering intensity in the near-UV to short-visible region (350-450 nm), relative to longer wavelengths, for fibrotic kidneys compared to normal kidney, with a quasi-linear correlation between the ESS changes and the histopathology-determined degree of IFTA. These results suggest the potential of ESS as an objective, quantitative and faster assessment of IFTA for the management of CKD patients and in the allocation of organs for kidney transplantation.
    Rights
    This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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    • ENG: Biomedical Engineering: Scholarly Papers [270]
    • BU Open Access Articles [3730]


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