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dc.contributor.authorLi, Baoqiangen_US
dc.contributor.authorEsipova, Tatiana V.en_US
dc.contributor.authorSencan, Ikbalen_US
dc.contributor.authorKılıç, Kıvılcımen_US
dc.contributor.authorFu, Buyinen_US
dc.contributor.authorDesjardins, Micheleen_US
dc.contributor.authorMoeini, Mohammaden_US
dc.contributor.authorKura, Sreekanthen_US
dc.contributor.authorYaseen, Mohammad A.en_US
dc.contributor.authorLesage, Fredericen_US
dc.contributor.authorØstergaard, Leifen_US
dc.contributor.authorDevor, Annaen_US
dc.contributor.authorBoas, David A.en_US
dc.contributor.authorVinogradov, Sergei A.en_US
dc.contributor.authorSakadžić, Savaen_US
dc.coverage.spatialEnglanden_US
dc.date2019-07-01
dc.date.accessioned2020-02-05T16:28:22Z
dc.date.available2020-02-05T16:28:22Z
dc.date.issued2019-07-15
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/31305237
dc.identifier.citationBaoqiang Li, Tatiana V Esipova, Ikbal Sencan, Kıvılcım Kılıç, Buyin Fu, Michele Desjardins, Mohammad Moeini, Sreekanth Kura, Mohammad A Yaseen, Frederic Lesage, Leif Østergaard, Anna Devor, David A Boas, Sergei A Vinogradov, Sava Sakadžić. 2019. "More homogeneous capillary flow and oxygenation in deeper cortical layers correlate with increased oxygen extraction.." Elife, Volume 8, https://doi.org/10.7554/eLife.42299
dc.identifier.issn2050-084X
dc.identifier.urihttps://hdl.handle.net/2144/39281
dc.description.abstractOur understanding of how capillary blood flow and oxygen distribute across cortical layers to meet the local metabolic demand is incomplete. We addressed this question by using two-photon imaging of resting-state microvascular oxygen partial pressure (PO2) and flow in the whisker barrel cortex in awake mice. Our measurements in layers I-V show that the capillary red-blood-cell flux and oxygenation heterogeneity, and the intracapillary resistance to oxygen delivery, all decrease with depth, reaching a minimum around layer IV, while the depth-dependent oxygen extraction fraction is increased in layer IV, where oxygen demand is presumably the highest. Our findings suggest that more homogeneous distribution of the physiological observables relevant to oxygen transport to tissue is an important part of the microvascular network adaptation to local brain metabolism. These results will inform the biophysical models of layer-specific cerebral oxygen delivery and consumption and improve our understanding of the diseases that affect cerebral microcirculation.en_US
dc.description.sponsorshipNS092986 - NIH HHS; R01 EB018464 - NIBIB NIH HHS; MH111359 - NIH HHS; EB018464 - NIH HHS; R24 NS092986 - NINDS NIH HHS; AA027097 - NIH HHS; R01 NS091230 - NINDS NIH HHS; NS091230 - NIH HHS; NS055104 - NIH HHS; U01 HL133362 - NHLBI NIH HHS; P01 NS055104 - NINDS NIH HHS; R01 MH111359 - NIMH NIH HHSen_US
dc.languageeng
dc.relation.ispartofElife
dc.rightsCopyright © 2019, Li et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCapillary blood flowen_US
dc.subjectCapillary oxygenationen_US
dc.subjectCerebral cortexen_US
dc.subjectMouseen_US
dc.subjectNeuroscienceen_US
dc.subjectPartial pressure of oxygenen_US
dc.subjectTwo-photon phosphorescence lifetime microscopyen_US
dc.subjectAnimalsen_US
dc.subjectCapillariesen_US
dc.subjectCerebral cortexen_US
dc.subjectCerebrovascular circulationen_US
dc.subjectMiceen_US
dc.subjectOxygenen_US
dc.subjectPartial pressureen_US
dc.subjectBiochemistry and cell biologyen_US
dc.titleMore homogeneous capillary flow and oxygenation in deeper cortical layers correlate with increased oxygen extractionen_US
dc.typeArticleen_US
dc.description.versionPublished versionen_US
dc.identifier.doi10.7554/eLife.42299
pubs.elements-sourcepubmeden_US
pubs.notesEmbargo: Not knownen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Engineeringen_US
pubs.organisational-groupBoston University, College of Engineering, Department of Biomedical Engineeringen_US
pubs.publication-statusPublished onlineen_US
dc.identifier.orcid0000-0002-6709-7711 (Boas, David A)
dc.identifier.mycv482078


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Copyright © 2019, Li et al.

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
Except where otherwise noted, this item's license is described as Copyright © 2019, Li et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.