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dc.contributor.advisorWong, Wilson W.en_US
dc.contributor.authorSofjan, Katri Jeanneen_US
dc.date.accessioned2020-02-12T14:52:40Z
dc.date.available2020-02-12T14:52:40Z
dc.date.issued2020
dc.identifier.urihttps://hdl.handle.net/2144/39339
dc.description.abstractThe endogenous immune system is a complex consortium of cells which must interact to effectively detect and respond to threats. Communication between cells, either through direct contact or by secreted chemokines and cytokines, is integral to the immune system’s function. The ability to rewire these communications and program coordinated behavior in a multicellular immune network would open new doors in the field of cell therapies for cancer and other diseases, as well as enabling investigation of the design rules for cell consortia. Previous efforts to engineer population-level immune cell behavior have largely been limited to secretion of soluble factors, which are nonspecific actors and do not enable directed communication between specific cell types. Here, we develop a framework for user-specified communication between engineered immune cells. We design and construct genetic circuits which enable the secretion of the adaptor molecule for a split CAR system in an activation-dependent manner, enabling modulation of the function of nearby cells. This novel cell to cell communication system enables programming of interactions between immune cells and provides a framework for the construction of complex cellular consortia.en_US
dc.language.isoen_US
dc.rightsAttribution-NoDerivatives 4.0 Internationalen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nd/4.0/
dc.subjectBiomedical engineeringen_US
dc.subjectCAR-Ten_US
dc.subjectCommunicationen_US
dc.subjectImmunologyen_US
dc.subjectSynthetic biologyen_US
dc.titleEngineered immune cell consortiumen_US
dc.typeThesis/Dissertationen_US
dc.date.updated2020-01-29T02:01:58Z
etd.degree.nameMaster of Scienceen_US
etd.degree.levelmastersen_US
etd.degree.disciplineBiomedical Engineeringen_US
etd.degree.grantorBoston Universityen_US
dc.identifier.orcid0000-0003-1133-7824


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Attribution-NoDerivatives 4.0 International
Except where otherwise noted, this item's license is described as Attribution-NoDerivatives 4.0 International