Show simple item record

dc.contributor.authorKort, Naomi S.en_US
dc.contributor.authorFord, Judith M.en_US
dc.contributor.authorRoach, Brian J.en_US
dc.contributor.authorGunduz-Bruce, Handanen_US
dc.contributor.authorKrystal, John H.en_US
dc.contributor.authorJaeger, Judithen_US
dc.contributor.authorReinhart, Robert M.G.en_US
dc.contributor.authorMathalon, Daniel H.en_US
dc.date.accessioned2020-02-13T15:20:08Z
dc.date.available2020-02-13T15:20:08Z
dc.date.issued2017-03-15
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000397300000010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=6e74115fe3da270499c3d65c9b17d654
dc.identifier.citationN.S. Kort, J.M. Ford, B.J. Roach, H. Gunduz-Bruce, J.H. Krystal, J. Jaeger, R.M.G. Reinhart, D.H. Mathalon. 2017. "Role of N-Methyl-D-Aspartate Receptors in Action-Based Predictive Coding Deficits in Schizophrenia." Biological Psychiatry, Volume 81, Issue 6, pp. 514 - 524. https://doi.org/10.1016/j.biopsych.2016.06.019
dc.identifier.issn0006-3223
dc.identifier.issn1873-2402
dc.identifier.urihttps://hdl.handle.net/2144/39372
dc.descriptionPublished in final edited form as:Biol Psychiatry. 2017 March 15; 81(6): 514–524. doi:10.1016/j.biopsych.2016.06.019.en_US
dc.description.abstractBACKGROUND: Recent theoretical models of schizophrenia posit that dysfunction of the neural mechanisms subserving predictive coding contributes to symptoms and cognitive deficits, and this dysfunction is further posited to result from N-methyl-D-aspartate glutamate receptor (NMDAR) hypofunction. Previously, by examining auditory cortical responses to self-generated speech sounds, we demonstrated that predictive coding during vocalization is disrupted in schizophrenia. To test the hypothesized contribution of NMDAR hypofunction to this disruption, we examined the effects of the NMDAR antagonist, ketamine, on predictive coding during vocalization in healthy volunteers and compared them with the effects of schizophrenia. METHODS: In two separate studies, the N1 component of the event-related potential elicited by speech sounds during vocalization (talk) and passive playback (listen) were compared to assess the degree of N1 suppression during vocalization, a putative measure of auditory predictive coding. In the crossover study, 31 healthy volunteers completed two randomly ordered test days, a saline day and a ketamine day. Event-related potentials during the talk/listen task were obtained before infusion and during infusion on both days, and N1 amplitudes were compared across days. In the case-control study, N1 amplitudes from 34 schizophrenia patients and 33 healthy control volunteers were compared. RESULTS: N1 suppression to self-produced vocalizations was significantly and similarly diminished by ketamine (Cohen’s d = 1.14) and schizophrenia (Cohen’s d = .85). CONCLUSIONS: Disruption of NMDARs causes dysfunction in predictive coding during vocalization in a manner similar to the dysfunction observed in schizophrenia patients, consistent with the theorized contribution of NMDAR hypofunction to predictive coding deficits in schizophrenia.en_US
dc.description.sponsorshipThis work was supported by AstraZeneca for an investigator-initiated study (DHM) and the National Institute of Mental Health Grant Nos. R01 MH-58262 (to JMF) and T32 MH089920 (to NSK). JHK was supported by the Yale Center for Clinical Investigation Grant No. UL1RR024139 and the US National Institute on Alcohol Abuse and Alcoholism Grant No. P50AA012879. (AstraZeneca for an investigator-initiated study (DHM); R01 MH-58262 - National Institute of Mental Health; T32 MH089920 - National Institute of Mental Health; UL1RR024139 - Yale Center for Clinical Investigation; P50AA012879 - US National Institute on Alcohol Abuse and Alcoholism)en_US
dc.format.extentp. 514 - 524en_US
dc.languageEnglish
dc.publisherElsevieren_US
dc.relation.ispartofBiological Psychiatry
dc.subjectScience & technologyen_US
dc.subjectLife sciences & biomedicineen_US
dc.subjectNeurosciencesen_US
dc.subjectPsychiatryen_US
dc.subjectNeurosciences & neurologyen_US
dc.subjectElectroencephalographyen_US
dc.subjectKetamineen_US
dc.subjectN-methyl-D-aspartate glutamate receptoren_US
dc.subjectPredictive codingen_US
dc.subjectSchizophreniaen_US
dc.subjectSpeech motor controlen_US
dc.subjectAcoustic stimulationen_US
dc.subjectAdulten_US
dc.subjectCerebral cortexen_US
dc.subjectCross-over studiesen_US
dc.subjectEvoked potentialsen_US
dc.subjectFemaleen_US
dc.subjectHumansen_US
dc.subjectKetamineen_US
dc.subjectMaleen_US
dc.subjectReceptors, N-methyl-D-aspartateen_US
dc.subjectSchizophrenic psychologyen_US
dc.subjectSpeech perceptionen_US
dc.subjectBiological sciencesen_US
dc.subjectPsychology and cognitive sciencesen_US
dc.subjectMedical and health sciencesen_US
dc.subjectPsychiatryen_US
dc.titleRole of N-methyl-D-aspartate receptors in action-based predictive coding deficits in schizophreniaen_US
dc.typeArticleen_US
dc.description.versionAccepted manuscripten_US
dc.identifier.doi10.1016/j.biopsych.2016.06.019
pubs.elements-sourcemanual-entryen_US
pubs.notesEmbargo: Not knownen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Arts & Sciencesen_US
pubs.organisational-groupBoston University, College of Arts & Sciences, Department of Psychological & Brain Sciencesen_US
pubs.publication-statusPublisheden_US
dc.identifier.mycv185259


This item appears in the following Collection(s)

Show simple item record