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dc.contributor.authorUdwan, Khalilen_US
dc.contributor.authorAbed, Ahmeden_US
dc.contributor.authorRoth, Isabelleen_US
dc.contributor.authorDizin, Evaen_US
dc.contributor.authorMaillard, Marcen_US
dc.contributor.authorBettoni, Carlaen_US
dc.contributor.authorLoffing, Johannesen_US
dc.contributor.authorWagner, Carsten A.en_US
dc.contributor.authorEdwards, Aurelieen_US
dc.contributor.authorFeraille, Ericen_US
dc.date.accessioned2020-02-19T19:21:52Z
dc.date.available2020-02-19T19:21:52Z
dc.date.issued2017-11-15
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000417113000019&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=6e74115fe3da270499c3d65c9b17d654
dc.identifier.citationKhalil Udwan, Ahmed Abed, Isabelle Roth, Eva Dizin, Marc Maillard, Carla Bettoni, Johannes Loffing, Carsten A Wagner, Aurelie Edwards, Eric Feraille. 2017. "Dietary sodium induces a redistribution of the tubular metabolic workload." JOURNAL OF PHYSIOLOGY, Volume 595, Issue 22, pp. 6905 - 6922 (18). https://doi.org/10.1113/JP274927
dc.identifier.issn0022-3751
dc.identifier.issn1469-7793
dc.identifier.urihttps://hdl.handle.net/2144/39450
dc.description.abstractNa+ excretion by the kidney varies according to dietary Na+ intake. We undertook a systematic study of the effects of dietary salt intake on glomerular filtration rate (GFR) and tubular Na+ reabsorption. We examined the renal adaptive response in mice subjected to 7 days of a low sodium diet (LSD) containing 0.01% Na+, a normal sodium diet (NSD) containing 0.18% Na+ and a moderately high sodium diet (HSD) containing 1.25% Na+. As expected, LSD did not alter measured GFR and increased the abundance of total and cell‐surface NHE3, NKCC2, NCC, α‐ENaC and cleaved γ‐ENaC compared to NSD. Mathematical modelling predicted that tubular Na+ reabsorption increased in the proximal tubule but decreased in the distal nephron because of diminished Na+ delivery. This prediction was confirmed by the natriuretic response to diuretics targeting the thick ascending limb, the distal convoluted tubule or the collecting system. On the other hand, HSD did not alter measured GFR but decreased the abundance of the aforementioned transporters compared to NSD. Mathematical modelling predicted that tubular Na+ reabsorption decreased in the proximal tubule but increased in distal segments with lower transport efficiency with respect to O2 consumption. This prediction was confirmed by the natriuretic response to diuretics. The activity of the metabolic sensor adenosine monophosphate‐activated protein kinase (AMPK) was related to the changes in tubular Na+ reabsorption. Our data show that fractional Na+ reabsorption is distributed differently according to dietary Na+ intake and induces changes in tubular O2 consumption and sodium transport efficiency.en_US
dc.description.sponsorshipThis work was supported by the National Centre of Competence in Research Kidney control of homeostasis and a Swiss National Science Foundation grant 31003A 156736/1 to EF, 310030 143929/1 to JL and 31003A 155959 to CAW. KU received funding within the framework of IKPP2 from the EuropeanUnion's Seventh Framework Programme for research, technological development and demonstration under grant agreement no. 608847. (National Centre of Competence in Research Kidney control of homeostasis; 31003A 156736/1 - Swiss National Science Foundation; 310030 143929/1 - Swiss National Science Foundation; 31003A 155959 - Swiss National Science Foundation; 608847 - EuropeanUnion's Seventh Framework Programme for research, technological development and demonstration)en_US
dc.format.extent6905 - 6922 (18)en_US
dc.languageEnglish
dc.publisherWILEYen_US
dc.relation.ispartofJOURNAL OF PHYSIOLOGY
dc.rights© 2017 The Authors. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectScience & technologyen_US
dc.subjectLife sciences & biomedicineen_US
dc.subjectNeurosciencesen_US
dc.subjectPhysiologyen_US
dc.subjectNeurosciences & neurologyen_US
dc.subjectNa+ transporten_US
dc.subjectNa+ transportersen_US
dc.subjectDietary salten_US
dc.subjectDiureticsen_US
dc.subjectOptimal Na+ dieten_US
dc.subjectAdaptation, physiologicalen_US
dc.subjectAnimalsen_US
dc.subjectGlomerular filtration rateen_US
dc.subjectKidney tubules, proximalen_US
dc.subjectMaleen_US
dc.subjectMiceen_US
dc.subjectMice, inbred C57BLen_US
dc.subjectOxygenen_US
dc.subjectRenal eliminationen_US
dc.subjectRenal reabsorptionen_US
dc.subjectSodium, dietaryen_US
dc.subjectKidney tubules, proximalen_US
dc.subjectBiological sciencesen_US
dc.subjectMedical and health sciencesen_US
dc.subjectPhysiologyen_US
dc.titleDietary sodium induces a redistribution of the tubular metabolic workloaden_US
dc.typeArticleen_US
dc.description.versionPublished versionen_US
dc.identifier.doi10.1113/JP274927
pubs.elements-sourceweb-of-scienceen_US
pubs.notesEmbargo: Not knownen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Engineeringen_US
pubs.organisational-groupBoston University, College of Engineering, Department of Biomedical Engineeringen_US
pubs.publication-statusPublisheden_US
dc.identifier.mycv283164


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© 2017 The Authors. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as © 2017 The Authors. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.