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dc.contributor.authorGranjon, Daviden_US
dc.contributor.authorBonny, Olivieren_US
dc.contributor.authorEdwards, Aurelieen_US
dc.date.accessioned2020-02-26T20:51:11Z
dc.date.available2020-02-26T20:51:11Z
dc.date.issued2017-12-01
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000416873000002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=6e74115fe3da270499c3d65c9b17d654
dc.identifier.citationDavid Granjon, Olivier Bonny, Aurelie Edwards. 2017. "Coupling between phosphate and calcium homeostasis: a mathematical model." AMERICAN JOURNAL OF PHYSIOLOGY: RENAL PHYSIOLOGY, Volume 313, Issue 6, pp. F1181 - F1199. https://doi.org/10.1152/ajprenal.00271.2017
dc.identifier.issn1931-857X
dc.identifier.issn1522-1466
dc.identifier.urihttps://hdl.handle.net/2144/39546
dc.description.abstractCoupling between phosphate and calcium homeostasis: a mathematical model. Am J Physiol Renal Physiol 313: F1181–F1199, 2017. First published July 26, 2017; doi:10.1152/ajprenal.00271.2017.—We developed a mathematical model of calcium (Ca) and phosphate (PO4) homeostasis in the rat to elucidate the hormonal mechanisms that underlie the regulation of Ca and PO4 balance. The model represents the exchanges of Ca and PO4 between the intestine, plasma, kidneys, bone, and the intracellular compartment, and the formation of Ca-PO4-fetuin-A complexes. It accounts for the regulation of these fluxes by parathyroid hormone (PTH), vitamin D3, fibroblast growth factor 23, and Ca2-sensing receptors. Our results suggest that the Ca and PO4 homeostatic systems are robust enough to handle small perturbations in the production rate of either PTH or vitamin D3. The model predicts that large perturbations in PTH or vitamin D3 synthesis have a greater impact on the plasma concentration of Ca2 ([Ca2]p) than on that of PO4 ([PO4]p); due to negative feedback loops, [PO4]p does not consistently increase when the production rate of PTH or vitamin D3 is decreased. Our results also suggest that, following a large PO4 infusion, the rapidly exchangeable pool in bone acts as a fast, transient storage PO4 compartment (on the order of minutes), whereas the intracellular pool is able to store greater amounts of PO4 over several hours. Moreover, a large PO4 infusion rapidly lowers [Ca2]p owing to the formation of CaPO4 complexes. A large Ca infusion, however, has a small impact on [PO4]p, since a significant fraction of Ca binds to albumin. This mathematical model is the first to include all major regulatory factors of Ca and PO4 homeostasis.en_US
dc.description.sponsorshipO. Bonny is supported by Swiss National Science Foundation Grant 310030-163340 and by the special program Swiss National Centre of Competence in Research Kidney. D. Granjon was partially supported by a grant from the Faculte de Biologie et Medecine at the University of Lausanne. (310030-163340 - Swiss National Science Foundation; special program Swiss National Centre of Competence in Research Kidney; Faculte de Biologie et Medecine at the University of Lausanne)en_US
dc.format.extentF1181 - F1199 (19)en_US
dc.languageEnglish
dc.publisherAMER PHYSIOLOGICAL SOCen_US
dc.relation.ispartofAMERICAN JOURNAL OF PHYSIOLOGY: RENAL PHYSIOLOGY
dc.subjectScience & technologyen_US
dc.subjectLife sciences & biomedicineen_US
dc.subjectPhysiologyen_US
dc.subjectUrology & nephrologyen_US
dc.subjectCalciumen_US
dc.subjectPhosphateen_US
dc.subjectPTHen_US
dc.subjectVitamin D-3en_US
dc.subjectFGF23en_US
dc.subjectHomeostasisen_US
dc.subjectMathematical modelen_US
dc.subjectVitamin D3en_US
dc.subjectAnimalsen_US
dc.subjectBone and bonesen_US
dc.subjectCalcium phosphatesen_US
dc.subjectCholecalciferolen_US
dc.subjectFeedback, physiologicalen_US
dc.subjectFemaleen_US
dc.subjectFibroblast growth factorsen_US
dc.subjectIntestinal mucosaen_US
dc.subjectKidneyen_US
dc.subjectMaleen_US
dc.subjectMice, inbred C57BLen_US
dc.subjectModels, biologicalen_US
dc.subjectParathyroid hormoneen_US
dc.subjectReceptors, calcium-sensingen_US
dc.subjectAlpha-2-HS-glycoproteinen_US
dc.subjectIntestinesen_US
dc.subjectPhysiologyen_US
dc.subjectMedical physiologyen_US
dc.titleCoupling between phosphate and calcium homeostasis: a mathematical modelen_US
dc.typeArticleen_US
dc.description.versionAccepted manuscripten_US
dc.identifier.doi10.1152/ajprenal.00271.2017
pubs.elements-sourceweb-of-scienceen_US
pubs.notesEmbargo: Not knownen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Engineeringen_US
pubs.organisational-groupBoston University, College of Engineering, Department of Biomedical Engineeringen_US
pubs.publication-statusPublisheden_US
dc.identifier.mycv292412


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