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dc.contributor.authorMunoz, Ana-Mariaen_US
dc.date.accessioned2020-03-04T16:43:20Z
dc.date.available2020-03-04T16:43:20Z
dc.date.issued1992
dc.date.submitted1992
dc.identifier.urihttps://hdl.handle.net/2144/39687
dc.descriptionPLEASE NOTE: This work is protected by copyright. Downloading is restricted to the BU community: please click Download and log in with a valid BU account to access. If you are the author of this work and would like to make it publicly available, please contact open-help@bu.edu.en_US
dc.descriptionThesis (M.Sc.D.)--Boston University, Henry M. Goldman School of Graduate Dentistry, 1992 (Oral Biology).en_US
dc.descriptionviii, 104 leaves : col. ill.en_US
dc.descriptionIncludes bibliography (leaves 90-104).en_US
dc.description.abstractIt has been demonstrated that endotoxin plays a role in the destructive changes seen in periodontal disease. The purpose of this study was to quantify the levels of detectable endotoxins in subgingival plaque and saliva, before and after wearing fixed orthodontic appliances; to study: 1) if endotoxin production occured to any appreciable extent owning to mechanical capture of oral microflora and the development of plaque in orthodontic appliances, 2) the relationship of endotoxin to the proportion of gram-negative and gram-positive microorganisms and to the frequency of gingivitis found during an orthodontic treatment. A comparable clinical study was done before and one month after the placement of fixed orthodontic appliances in patients between 16-25 year old, undergoing orthodontic therapy. Clinical (plaque index, gingival index, and pocket depth) and microbiological data were recorded for the maxillary left central incisor, maxillary right first molar, mandibular right central incisor and mandibular left first molar. Comparisons included before and after assessments of gingival inflammation, plaque index, pocket depth, plaque weight, and ratio of Gram-negative and Gram-positive bacteria and levels of endotoxins in plaque and in saliva. Within the limits of this study it can be concluded that: - Although one month after the placement of fixed orthodontic appliances, the plaque index, the gingival index and the plaque weight, showed significant increases, no differences were found in pocket depth, the ratio of Gram-negative and Gram-positive microorganisms, and in the levels of endotoxins in plaque. - In saliva, despite the small sample, the gram-stain showed a significant predominance of Gram-positive bacteria, but the endotoxin levels did not increase after appliances were placed. However, it should be noted that in none of the patients the endotoxin levels increased. -The flora and the environment one month after the placement of the appliances seemed to be compatible with health. However, this is a very early stage of the orthodontic therapy and it would be interesting and necessary to do a longitudinal study involving at least 6 months of the treatment. - These findings imply that the presence of fixed orthodontic appliances, per se, need not contribute to periodontal disease; the orthodontist should take advantage of this observation by emphasizing the importance of prophylactic programs for patient undergoing orthodontic treatment.en_US
dc.language.isoen_US
dc.publisherBoston Universityen_US
dc.rightsThis work is protected by copyright. Downloading is restricted to the BU community. If you are the author of this work and would like to make it publicly available, please contact open-help@bu.edu.en_US
dc.subjectEndotoxinsen_US
dc.subjectDental plaqueen_US
dc.subjectSalivaen_US
dc.subjectOrthodontic appliancesen_US
dc.titleEndotoxin levels in subgingival plaque and saliva in patients prior to and following fixed orthodontic appliances : a preliminary clinical studyen_US
dc.typeThesis/Dissertationen_US
etd.degree.nameMaster of Science in Oral Biologyen_US
etd.degree.levelmastersen_US
etd.degree.disciplineOral Biologyen_US
etd.degree.grantorBoston Universityen_US


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