Inhibition of immobilization bone atrophy in rats by 5-methyl 2-thiophenecarboxylic acid
Shay, Norbert J.
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It has previously been reported by Wells and LLoyd that 5-MTC has prolonged hypocalcemic and hypophosphatemiceffects and that it can inhibit the hypercalcemic actions of parathyroid hormone and Vitamin D. These effects of 5-MTC appear to stem from its ability to inhibit bone resorption; and the purpose of this study was to determine if the drug would affect the bone atrophy resulting from limb denervation. In young male rates, one leg was denervated by cutting femoral and sciatic nerves. Two weeks after denervation, dry weight and ash weight of the tibias/fibulas and femurs were reduced by 20%. The addition of 5-MTC (0.35%) to regular chow diet resulted in a 20-30% reduction in post-denervation atrophy and an 8-10% increase in the weight of all the leg bones. However, the addition of 5-MTC (0.50%)to the diet resulted in no reduction in post-denervation atrophy and showed no tendency to affect the weight of the bones generally. At the 0.35% level, there was no significant effect on blood calcium levels or on average growth.
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