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dc.contributor.authorGelastopoulos, Alexandrosen_US
dc.contributor.authorWhittington, Miles A.en_US
dc.contributor.authorKopell, Nancy J.en_US
dc.coverage.spatialUnited Statesen_US
dc.date.accessioned2020-04-03T13:58:56Z
dc.date.available2020-04-03T13:58:56Z
dc.date.issued2019-08-13
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/31371513
dc.identifier.citationAlexandros Gelastopoulos, Miles A Whittington, Nancy J Kopell. 2019. "Parietal low beta rhythm provides a dynamical substrate for a working memory buffer.." Proc Natl Acad Sci U S A, Volume 116, Issue 33, pp. 16613 - 16620. https://doi.org/10.1073/pnas.1902305116
dc.identifier.issn1091-6490
dc.identifier.urihttps://hdl.handle.net/2144/39953
dc.description.abstractWorking memory (WM) is a component of the brain's memory systems vital for interpretation of sequential sensory inputs and consequent decision making. Anatomically, WM is highly distributed over the prefrontal cortex (PFC) and the parietal cortex (PC). Here we present a biophysically detailed dynamical systems model for a WM buffer situated in the PC, making use of dynamical properties believed to be unique to this area. We show that the natural beta1 rhythm (12 to 20 Hz) of the PC provides a substrate for an episodic buffer that can synergistically combine executive commands (e.g., from PFC) and multimodal information into a flexible and updatable representation of recent sensory inputs. This representation is sensitive to distractors, it allows for a readout mechanism, and it can be readily terminated by executive input. The model provides a demonstration of how information can be usefully stored in the temporal patterns of activity in a neuronal network rather than just synaptic weights between the neurons in that network.en_US
dc.description.sponsorshipWellcome Trusten_US
dc.format.extentp. 16613 - 16620en_US
dc.languageeng
dc.language.isoen_US
dc.relation.ispartofProc Natl Acad Sci U S A
dc.rightsThis open access article is distributed under Creative Commons Attribution License 4.0 (CC-BY 4.0).en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectBiophysical modelen_US
dc.subjectCell assembliesen_US
dc.subjectFrontoparietal coordinationen_US
dc.titleParietal low beta rhythm provides a dynamical substrate for a working memory bufferen_US
dc.typeArticleen_US
dc.description.versionPublished versionen_US
dc.identifier.doi10.1073/pnas.1902305116
pubs.elements-sourcepubmeden_US
pubs.notesEmbargo: Not knownen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Arts & Sciencesen_US
pubs.organisational-groupBoston University, College of Arts & Sciences, Department of Mathematics & Statisticsen_US
pubs.publication-statusPublisheden_US
dc.identifier.orcid0000-0002-8568-8750 (Kopell, Nancy J)
dc.identifier.mycv483621


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This open access article is distributed under Creative Commons Attribution License 4.0 (CC-BY 4.0).
Except where otherwise noted, this item's license is described as This open access article is distributed under Creative Commons Attribution License 4.0 (CC-BY 4.0).