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dc.contributor.authorCui, Yingen_US
dc.contributor.authorCai, Mengen_US
dc.contributor.authorStanley, H. Eugeneen_US
dc.date.accessioned2020-04-03T14:12:15Z
dc.date.available2020-04-03T14:12:15Z
dc.date.issued2017-01-01
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000416885800001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=6e74115fe3da270499c3d65c9b17d654
dc.identifier.citationYing Cui, Meng Cai, H. Eugene Stanley. 2017. "Comparative Analysis and Classification of Cassette Exons and Constitutive Exons." BIOMED RESEARCH INTERNATIONAL. https://doi.org/10.1155/2017/7323508
dc.identifier.issn2314-6133
dc.identifier.issn2314-6141
dc.identifier.urihttps://hdl.handle.net/2144/39954
dc.description.abstractAlternative splicing (AS) is a major engine that drives proteome diversity in mammalian genomes and is a widespread cause of human hereditary diseases. More than 95% of genes in the human genome are alternatively spliced, and the most common type of AS is the cassette exon. Recent discoveries have demonstrated that the cassette exon plays an important role in genetic diseases. To discover the formation mechanism of cassette exon events, we statistically analyze cassette exons and find that cassette exon events are strongly influenced by individual exons that are smaller in size and that have a lower GC content, more codon terminations, and weaker splice sites. We propose an improved random-forest-based hybrid method of distinguishing cassette exons from constitutive exons. Our method achieves a high accuracy in classifying cassette exons and constitutive exons and is verified to outperform previous approaches. It is anticipated that this study will facilitate a better understanding of the underlying mechanisms in cassette exons.en_US
dc.description.sponsorshipThis work is supported by grants from the Natural Science Foundation of Shaanxi Province of China (no. 2016JQ6072), the National Natural Science Foundation of China (no. 71501153), Xi'an Science and Technology Program (no. XDKD001), and China Scholarship Council (201506965039, 201606965057). The Boston University Center for Polymer Studies is supported by NSF Grants PHY-1505000, CMMI-1125290, and CHE-1213217, by DTRA Grant HDTRA1-14-1-0017, and by DOE Contract DE-AC07-05Id14517. (2016JQ6072 - Natural Science Foundation of Shaanxi Province of China; 71501153 - National Natural Science Foundation of China; XDKD001 - Xi'an Science and Technology Program; 201506965039 - China Scholarship Council; 201606965057 - China Scholarship Council; PHY-1505000 - NSF; CMMI-1125290 - NSF; CHE-1213217 - NSF; HDTRA1-14-1-0017 - DTRA; DE-AC07-05Id14517 - DOE)en_US
dc.format.extent8 pagesen_US
dc.languageEnglish
dc.language.isoen_US
dc.publisherHindawi Ltden_US
dc.relation.ispartofBiomed Research International
dc.rightsCopyright © 2017 Ying Cui et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectScience & technologyen_US
dc.subjectLife sciences & biomedicineen_US
dc.subjectBiotechnology & applied microbiologyen_US
dc.subjectResearch & experimental medicineen_US
dc.subjectAlternative splicing eventsen_US
dc.subjectSupport vector machineen_US
dc.subjectIdentificationen_US
dc.subjectProteinen_US
dc.subjectRNAen_US
dc.subjectArabidopsisen_US
dc.subjectPredictionen_US
dc.subjectCanceren_US
dc.subjectGeneen_US
dc.subjectAlgorithmsen_US
dc.subjectAlternative splicingen_US
dc.subjectDatabases, geneticen_US
dc.subjectExonsen_US
dc.subjectGenome, humanen_US
dc.subjectHumansen_US
dc.subjectMachine learningen_US
dc.subjectSequence analysis, DNAen_US
dc.subjectInformation and computing sciencesen_US
dc.subjectTechnologyen_US
dc.titleComparative Analysis and Classification of Cassette Exons and Constitutive Exonsen_US
dc.typeArticleen_US
dc.description.versionPublished versionen_US
dc.identifier.doi10.1155/2017/7323508
pubs.elements-sourceweb-of-scienceen_US
pubs.notesEmbargo: Not knownen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Arts & Sciencesen_US
pubs.organisational-groupBoston University, College of Arts & Sciences, Department of Physicsen_US
pubs.publication-statusPublisheden_US
dc.identifier.mycv298117


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Copyright © 2017 Ying Cui et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as Copyright © 2017 Ying Cui et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.