The author explores a dialogue between Native American religion and culture, Christianity, and science, for the purpose of determining some ways in which Native American religious tradition can offer a helpful perspective and corrective for some of the theological and ethical dilemmas that arise from historical interrelatedness of science and \"conquering \" Christianity. A kind of secular Christianity-of-conquest has been used as a justification for unreflected and ethically dubious choices in science. Working with Trickster stories and concepts, is it possible to engage the teachings of Jesus in new and subtle ways to make critical assessments of developments in biotechnology?