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dc.contributor.authorBaumann, Cory W.en_US
dc.contributor.authorKwak, Dongminen_US
dc.contributor.authorThompson, LaDora V.en_US
dc.coverage.spatialUnited Statesen_US
dc.date2019-07-16
dc.date.accessioned2020-04-08T14:51:09Z
dc.date.available2020-04-08T14:51:09Z
dc.date.issued2019-07-29
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/31355774
dc.identifier.citationCory W. Baumann, Dongmin Kwak, LaDora V. Thompson. 2019. "Sex-specific components of frailty in C57BL/6 mice.." Aging (Albany NY), Volume 11, Issue 14, pp. 5206 - 5214. https://doi.org/10.18632/aging.102114
dc.identifier.issn1945-4589
dc.identifier.urihttps://hdl.handle.net/2144/40040
dc.description.abstractMany age-related biochemical, physiological and behavioral changes are known to be sex-specific. However, how sex influences frailty status and mortality risk in frail rodents has yet to be established. The purpose of this study was therefore to characterize sex differences in frail mice across the lifespan. Male (n=29) and female (n=27) mice starting at 17 months of age were assessed using a frailty phenotype adjusted according to sex, which included body weight, walking speed, strength, endurance and physical activity. Regardless of sex, frail mice were phenotypically dysfunctional compared to age-matched non-frail mice, while non-frail females generally possessed a higher body fat percentage and were more physically active than non-frail males (p≤0.05). The prevalence of frailty was greater in female mice at 26 months of age (p=0.05), but if normalized to mean lifespan, no sex differences remained. No differences were detected in the rate of death or mean lifespan between frail male and female mice (p≥0.12). In closing, these data indicate that sexual differences exist in aging C57BL/6 mice and if the frailty criteria are adjusted according to sex, the prevalence of frailty increases across age with frail mice dying early in life, regardless of sex.en_US
dc.description.sponsorshipT32 AG029796 - NIA NIH HHS; T32 AR007612 - NIAMS NIH HHSen_US
dc.format.extentpp. 5206 - 5214.en_US
dc.languageEnglish
dc.language.isoen_US
dc.relation.ispartofAging (Albany NY)
dc.rightsAttribution 3.0 Unporteden_US
dc.rights.urihttp://creativecommons.org/licenses/by/3.0
dc.subjectC57BL/6 miceen_US
dc.subjectFrailtyen_US
dc.subjectFrailty phenotypeen_US
dc.subjectHealth-survival paradoxen_US
dc.subjectSex differencesen_US
dc.subjectBiochemistry and cell biologyen_US
dc.subjectPhysiologyen_US
dc.subjectOncology and carcinogenesisen_US
dc.subjectDevelopmental biologyen_US
dc.titleSex-specific components of frailty in C57BL/6 mice.en_US
dc.typeArticleen_US
dc.description.versionPublished versionen_US
dc.identifier.doi10.18632/aging.102114
pubs.elements-sourcepubmeden_US
pubs.notesEmbargo: Not knownen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Health & Rehabilitation Sciences: Sargent Collegeen_US
pubs.organisational-groupBoston University, College of Health & Rehabilitation Sciences: Sargent College, Physical Therapy and Athletic Trainingen_US
pubs.publication-statusPublisheden_US
dc.identifier.mycv482967


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