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dc.contributor.authorKwak, Dongminen_US
dc.contributor.authorBaumann, Cory W.en_US
dc.contributor.authorThompson, LaDora V.en_US
dc.date.accessioned2020-04-08T14:59:57Z
dc.date.available2020-04-08T14:59:57Z
dc.date.issued2019-04-08
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/30958526
dc.identifier.citationDongmin Kwak, Cory W. Baumann, LaDora V. Thompson. 2019. "Identifying Characteristics of Frailty in Female Mice Using a Phenotype Assessment Tool.." J Gerontol A Biol Sci Med Sci, Volume 75, Issue 4, pp. 640 - 646. https://doi.org/10.1093/gerona/glz092
dc.identifier.issn1758-535X
dc.identifier.urihttps://hdl.handle.net/2144/40042
dc.description.abstractPreclinical studies are important in identifying the underlying mechanisms contributing to frailty. Frailty studies have mainly focused on male rodents with little directed at female rodents. Therefore, the purposes of this study were to identify the onset and prevalence of frailty across the life span in female mice, and to determine if frailty predicts mortality. Female C57BL/6 (n = 27) mice starting at 17 months of age were assessed across the life span using a frailty phenotype, which included body weight, walking speed, strength, endurance, and physical activity. The onset of frailty occurred at approximately 17 months (1/27 mice), with the prevalence of frailty increasing thereafter. At 17 months, 11.1% of the mice were pre-frail and by 26 months peaked at 36.9%. The percentage of frail mice progressively increased up to 66.7% at 32 months. Non-frail mice lived to 29 months whereas frail/pre-frail mice lived only to 26 months (p = .04). In closing, using a mouse frailty phenotype, we are able to identify that the prevalence of frailty in female mice increases across the life span and accurately predicts mortality. Together, this frailty phenotype has the potential to yield information about the underlying mechanisms contributing to frailty.en_US
dc.description.sponsorshipT32 AG029796 - NIA NIH HHSen_US
dc.format.extentpp. 640 - 646.en_US
dc.languageEnglish
dc.language.isoen_US
dc.relation.ispartofThe journals of gerontology. Series A, biological sciences and medical sciences
dc.rightsAttribution-NonCommercial 4.0 Internationalen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectAgingen_US
dc.subjectBody weighten_US
dc.subjectMortalityen_US
dc.subjectMuscleen_US
dc.subjectPhysical functionen_US
dc.subjectGerontologyen_US
dc.subjectClinical sciencesen_US
dc.titleIdentifying characteristics of frailty in female mice using a phenotype assessment toolen_US
dc.typeArticleen_US
dc.description.versionPublished versionen_US
dc.identifier.doi10.1093/gerona/glz092
pubs.elements-sourcemanual-entryen_US
pubs.notesEmbargo: Not knownen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Health & Rehabilitation Sciences: Sargent Collegeen_US
pubs.organisational-groupBoston University, College of Health & Rehabilitation Sciences: Sargent College, Physical Therapy and Athletic Trainingen_US
pubs.publication-statusPublisheden_US
dc.identifier.mycv457268


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Except where otherwise noted, this item's license is described as Attribution-NonCommercial 4.0 International