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    Neuroprotective effects of carnitinoid compounds in rodent cellular and in vivo models of mitochondrial complex I dysfunction

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    © 2018 Mesford Publisher INC. This is an open access article licensed under the term of the Creative Commons Attribution-Non Commercial 4.0 International License (Attribution-NonCommercial 4.0 International-CC-BY-NC 4.0)
    Date Issued
    2019-03-13
    Author(s)
    Steliou, Kosta
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    Permanent Link
    https://hdl.handle.net/2144/40078
    OA Version
    Published version
    Citation (published version)
    Kosta Steliou. 2019. "Neuroprotective effects of carnitinoid compounds in rodent cellular and in vivo models of mitochondrial complex I dysfunction." Volume 2, pp. 26 - 33.
    Abstract
    Rotenone-mediated mitochondrial complex I inhibition was used to model Parkinson’s disease-like syndrome in Lewis rats. Tyrosine hydroxylase immunolabeling demonstrated a decrease in the number of dopaminergic neurons as well as aberrant morphology in surviving neurons. Administration of carnitinoid compounds (synthetic lipoylcarnitine or butyrylcarnitine compounds) reduced dopaminergic neuronal cell loss with characteristic morphology observed in surviving neurons. In a rat primordial hippocampal cell line (H19-7/IGF-IR), rotenone treatment resulted in increased ROS and reduced cellular ATP, while co-treatment with lipoylcarnitine maintained ROS and ATP at control levels. These results illustrate the therapeutic potential of small-molecule carnitinoids in treating neurodegenerative diseases associated with mitochondrial dysfunction.
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    © 2018 Mesford Publisher INC. This is an open access article licensed under the term of the Creative Commons Attribution-Non Commercial 4.0 International License (Attribution-NonCommercial 4.0 International-CC-BY-NC 4.0)
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    • Cancer Center Papers [12]
    • MED: Biochemistry Papers [27]
    • BU Open Access Articles [4757]


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