Interferometric detection and enumeration of viral particles using Si-based microfluidics
Ozkumur, Ayca Yalcin
Kanik, Fulya Ekiz
Trueb, Jacob T.
Unlu, M. Selim
MetadataShow full item record
First author draft
Citation (published version)Ayca Yalcin Ozkumur, Fulya Ekiz Kanik, Jacob T Trueb, Celalettin Yurdakul, M Selim Unlu. 2019. "Interferometric Detection and Enumeration of Viral Particles using Si-Based Microfluidics." IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS, Volume 25, Issue 1, 7 pp. https://doi.org/10.1109/JSTQE.2018.2854548
Single-particle interferometric reflectance imaging sensor enables optical visualization and characterization of individual nanoparticles without any labels. Using this technique, we have shown end-point and real-time detection of viral particles using laminate-based active and passive cartridge configurations. Here, we present a new concept for low-cost microfluidic integration of the sensor chips into compact cartridges through utilization of readily available silicon fabrication technologies. This new cartridge configuration will allow simultaneous detection of individual virus binding events on a 9-spot microarray, and provide the needed simplicity and robustness for routine real-time operation for discrete detection of viral particles in a multiplex format.