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    Interferometric detection and enumeration of viral particles using Si-based microfluidics

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    Date Issued
    2019-01-01
    Publisher Version
    10.1109/JSTQE.2018.2854548
    Author(s)
    Ozkumur, Ayca Yalcin
    Kanik, Fulya Ekiz
    Trueb, Jacob T.
    Yurdakul, Celalettin
    Unlu, M. Selim
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    Permanent Link
    https://hdl.handle.net/2144/40112
    Version
    First author draft
    Citation (published version)
    Ayca Yalcin Ozkumur, Fulya Ekiz Kanik, Jacob T Trueb, Celalettin Yurdakul, M Selim Unlu. 2019. "Interferometric Detection and Enumeration of Viral Particles using Si-Based Microfluidics." IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS, Volume 25, Issue 1, 7 pp. https://doi.org/10.1109/JSTQE.2018.2854548
    Abstract
    Single-particle interferometric reflectance imaging sensor enables optical visualization and characterization of individual nanoparticles without any labels. Using this technique, we have shown end-point and real-time detection of viral particles using laminate-based active and passive cartridge configurations. Here, we present a new concept for low-cost microfluidic integration of the sensor chips into compact cartridges through utilization of readily available silicon fabrication technologies. This new cartridge configuration will allow simultaneous detection of individual virus binding events on a 9-spot microarray, and provide the needed simplicity and robustness for routine real-time operation for discrete detection of viral particles in a multiplex format.
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    • ENG: Electrical and Computer Engineering: Scholarly Papers [252]
    • BU Open Access Articles [3664]


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