Digital detection of biomarkers for low-cost, high-sensitivity diagnostics
Ünlü, M. Selim
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Citation (published version)M Selim Ünlü. "Digital detection of biomarkers for low-cost, high-sensitivity diagnostics." SPIE Newsroom, https://doi.org/10.1117/2.1201602.006318
We have demonstrated Interferometric Reflectance Imaging Sensor (IRIS) with the ability to detect single nanoscale particles. By extending single-particle IRIS to in-liquid dynamic imaging, we demonstrated real-time digital detection of individual viral pathogens as well as single molecules labeled with Au nanoparticles. With this technique we demonstrate real-time simultaneous detection of multiple targets in a single sample, as well as quantitative dynamic detection of individual biomolecular interactions for reaction kinetics measurements. This approach promises to simplify and reduce the cost of rapid diagnostics.
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