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dc.contributor.authorAvci, Oguzhanen_US
dc.contributor.authorUnlu, Nese Lortlaren_US
dc.contributor.authorOzkumur, Ayca Yalcinen_US
dc.contributor.authorUnlu, M. Selimen_US
dc.date.accessioned2020-04-13T15:43:55Z
dc.date.available2020-04-13T15:43:55Z
dc.date.issued2015-07-01
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000361788200144&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=6e74115fe3da270499c3d65c9b17d654
dc.identifier.citationOguzhan Avci, Nese Lortlar Unlu, Ayca Yalcin Ozkumur, M Selim Unlu. 2015. "Interferometric Reflectance Imaging Sensor (IRIS)-A Platform Technology for Multiplexed Diagnostics and Digital Detection." SENSORS, Volume 15, Issue 7, pp. 17649 - 17665 (17). https://doi.org/10.3390/s150717649
dc.identifier.issn1424-8220
dc.identifier.urihttps://hdl.handle.net/2144/40125
dc.description.abstractOver the last decade, the growing need in disease diagnostics has stimulated rapid development of new technologies with unprecedented capabilities. Recent emerging infectious diseases and epidemics have revealed the shortcomings of existing diagnostics tools, and the necessity for further improvements. Optical biosensors can lay the foundations for future generation diagnostics by providing means to detect biomarkers in a highly sensitive, specific, quantitative and multiplexed fashion. Here, we review an optical sensing technology, Interferometric Reflectance Imaging Sensor (IRIS), and the relevant features of this multifunctional platform for quantitative, label-free and dynamic detection. We discuss two distinct modalities for IRIS: (i) low-magnification (ensemble biomolecular mass measurements) and (ii) high-magnification (digital detection of individual nanoparticles) along with their applications, including label-free detection of multiplexed protein chips, measurement of single nucleotide polymorphism, quantification of transcription factor DNA binding, and high sensitivity digital sensing and characterization of nanoparticles and viruses.en_US
dc.description.sponsorshipA number of people have contributed to the body of work reviewed in this article. We are particularly indebted to Marcella Chiari and Marina Cretich of CNR, Milan, and John Connor, Bennett Goldberg, Emre Ozkumur, Sunmin Ahn, George Daaboul, Margo Monroe, Alex Reddington, Carlos Lopez, Abdulkadir Yurt, and Rahul Vedula of Boston University, as well as other current and past members of the Unlu lab at Boston University. Funding support for the interferometric reflectance imaging sensor (IRIS) research has been provided by a variety of sources including National Institutes of Health (R21 GM074872-01A1, R21EB015900, R01AI1096159) Army Research Laboratory (W911NF-06-2-0040), National Science Foundation (OISE-0601631, EEC-0812056, AIR-1127833), MITRE Corporation, Center for Integration of Medicine and Innovative Technology (CIMIT). O. Avci acknowledges support from Bahcesehir University-Boston University fellowship. (R21 GM074872-01A1 - National Institutes of Health; R21EB015900 - National Institutes of Health; R01AI1096159 - National Institutes of Health; W911NF-06-2-0040 - Army Research Laboratory; OISE-0601631 - National Science Foundation; EEC-0812056 - National Science Foundation; AIR-1127833 - National Science Foundation; MITRE Corporation; Center for Integration of Medicine and Innovative Technology (CIMIT); Bahcesehir University-Boston University fellowship)en_US
dc.format.extentp. 17649 - 17665en_US
dc.languageEnglish
dc.language.isoen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofSENSORS
dc.rightsThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectScience & technologyen_US
dc.subjectPhysical sciencesen_US
dc.subjectChemistry, analyticalen_US
dc.subjectElectrochemistryen_US
dc.subjectInstruments & instrumentationen_US
dc.subjectChemistryen_US
dc.subjectOptical biosensoren_US
dc.subjectInterferometryen_US
dc.subjectLabel-freeen_US
dc.subjectDigital detectionen_US
dc.subjectNanoparticleen_US
dc.subjectVirusen_US
dc.subjectSingle nucleotide polymorphismen_US
dc.subjectSingle nanoparticle detectionen_US
dc.subjectWhispering-gallery-modeen_US
dc.subjectBiomolecular interactionsen_US
dc.subjectVirus detectionen_US
dc.subjectDNAen_US
dc.subjectBiosensorsen_US
dc.subjectHybridizationen_US
dc.subjectMicroarraysen_US
dc.subjectAdsorptionen_US
dc.subjectBiosensing techniquesen_US
dc.subjectDiagnostic imagingen_US
dc.subjectHumansen_US
dc.subjectSignal processing, computer-assisteden_US
dc.subjectElectrical and electronic engineeringen_US
dc.subjectEnvironmental science and managementen_US
dc.subjectEcologyen_US
dc.titleInterferometric Reflectance Imaging Sensor (IRIS)-a platform technology for multiplexed diagnostics and digital detectionen_US
dc.typeArticleen_US
dc.description.versionPublished versionen_US
dc.identifier.doi10.3390/s150717649
pubs.elements-sourceweb-of-scienceen_US
pubs.notesEmbargo: Not knownen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, Administrationen_US
pubs.organisational-groupBoston University, College of Engineeringen_US
pubs.organisational-groupBoston University, College of Engineering, Department of Biomedical Engineeringen_US
pubs.organisational-groupBoston University, College of Engineering, Department of Electrical & Computer Engineeringen_US
pubs.publication-statusPublisheden_US
dc.identifier.orcid0000-0002-8594-892X (Unlu, M Selim)
dc.identifier.mycv41080


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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.